Recombinant Human GLRX

• Cat.No.: GLRX-27691TH
• Product Overview: Recombinant full length Human Glutaredoxin 1; amino acids 1-106 , 11.7kDa.

Specification

• Description: This gene encodes a member of the glutaredoxin family. The encoded protein is a cytoplasmic enzyme catalyzing the reversible reduction of glutathione-protein mixed disulfides. This enzyme highly contributes to the antioxidant defense system. It is crucial for several signalling pathways by controlling the S-glutathionylation status of signalling mediators. It is involved in beta-amyloid toxicity and Alzheimers disease. Multiple alternatively spliced transcript variants encoding the same protein have been identified.
• Source: E. coli
• Form: Liquid
• Purity: >95% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 10% Glycerol, 20mM Tris HCl, 1mM DTT, pH 8.0
• Storage: Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Sequences of amino acids: MAQEFVNCKI QPGKVVVFIK PTCPYCRRAQ EILSQLPIKQ GLLEFVDITA TNHTNEIQDY LQQLTGARTV PRVFIGKDCI GGCSDLVSLQ QSGELLTRLK QIGALQ
• Sequence Similarities: Belongs to the glutaredoxin family.Contains 1 glutaredoxin domain.

Gene Information

• Gene Name: GLRX glutaredoxin (thioltransferase) [ Homo sapiens ]
• Official Symbol: GLRX
• Synonyms: GLRX; glutaredoxin (thioltransferase); glutaredoxin-1; GRX; GRX1
• Gene ID: 2745
• mRNA Refseq: NM_001118890
• Protein Refseq: NP_001112362
• MIM: 600443
• Uniprot ID: P35754
• Chromosome Location: 5q14
• Pathway: Metabolism, organism-specific biosystem; Metabolism of nucleotides, organism-specific biosystem; Synthesis and interconversion of nucleotide di- and triphosphates, organism-specific biosystem; ascorbate glutathione cycle, conserved biosystem
• Function: electron carrier activity; glutathione disulfide oxidoreductase activity; protein N-terminus binding; protein disulfide oxidoreductase activity