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Recombinant Human GLRX

Cat.No. : GLRX-27691TH
Product Overview : Recombinant full length Human Glutaredoxin 1; amino acids 1-106 , 11.7kDa.
Description : This gene encodes a member of the glutaredoxin family. The encoded protein is a cytoplasmic enzyme catalyzing the reversible reduction of glutathione-protein mixed disulfides. This enzyme highly contributes to the antioxidant defense system. It is crucial for several signalling pathways by controlling the S-glutathionylation status of signalling mediators. It is involved in beta-amyloid toxicity and Alzheimers disease. Multiple alternatively spliced transcript variants encoding the same protein have been identified.
Source : E. coli
Form : Liquid
Purity : >95% by SDS-PAGE
Storage buffer : Preservative: NoneConstituents: 10% Glycerol, 20mM Tris HCl, 1mM DTT, pH 8.0
Storage : Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Sequences of amino acids : MAQEFVNCKI QPGKVVVFIK PTCPYCRRAQ EILSQLPIKQ GLLEFVDITA TNHTNEIQDY LQQLTGARTV PRVFIGKDCI GGCSDLVSLQ QSGELLTRLK QIGALQ
Sequence Similarities : Belongs to the glutaredoxin family.Contains 1 glutaredoxin domain.
Gene Name : GLRX glutaredoxin (thioltransferase) [ Homo sapiens ]
Official Symbol : GLRX
Synonyms : GLRX; glutaredoxin (thioltransferase); glutaredoxin-1; GRX; GRX1;
Gene ID : 2745
mRNA Refseq : NM_001118890
Protein Refseq : NP_001112362
MIM : 600443
Uniprot ID : P35754
Chromosome Location : 5q14
Pathway : Metabolism, organism-specific biosystem; Metabolism of nucleotides, organism-specific biosystem; Synthesis and interconversion of nucleotide di- and triphosphates, organism-specific biosystem; ascorbate glutathione cycle, conserved biosystem;
Function : electron carrier activity; glutathione disulfide oxidoreductase activity; protein N-terminus binding; protein disulfide oxidoreductase activity;

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