|Product Overview :
||Full length native mature human Alanine Transaminase protein.
||This gene encodes cytosolic alanine aminotransaminase 1 (ALT1); also known as glutamate-pyruvate transaminase 1. This enzyme catalyzes the reversible transamination between alanine and 2-oxoglutarate to generate pyruvate and glutamate and, therefore, plays a key role in the intermediary metabolism of glucose and amino acids. Serum activity levels of this enzyme are routinely used as a biomarker of liver injury caused by drug toxicity, infection, alcohol, and steatosis. A related gene on chromosome 16 encodes a putative mitochondrial alanine aminotransaminase.
|Tissue specificity :
||Liver, kidney, heart, and skeletal muscles. Expressed at moderate levels in the adipose tissue.
||Ammonium Sulphate Precipitation
|Storage buffer :
||Constituent:41% Ammonium sulphate
||Aliquot and store at -80°C. Avoid repeated freeze / thaw cycles.
|Sequence Similarities :
||Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. Alanine aminotransferase subfamily.