Recombinant Human GRIA3

• Cat.No.: GRIA3-27524TH
• Product Overview: Recombinant fragment of Human Glutamate receptor 3 with N-Terminal proprietary tag. Mol Wt 36.63 kDa inclusive of tag.

Specification

• Description: Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes composed of multiple subunits, arranged to form ligand-gated ion channels. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The subunit encoded by this gene belongs to a family of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate)-sensitive glutamate receptors, and is subject to RNA editing (AGA->GGA; R->G). Alternative splicing at this locus results in different isoforms, which may vary in their signal transduction properties.
• Protein length: 100 amino acids
• Molecular Weight: 36.630kDa inclusive of tags
• Source: Wheat germ
• Form: Liquid
• Purity: Proprietary Purification
• Storage buffer: pH: 8.00Constituents:0.3% Glutathione, 0.79% Tris HCl
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequences of amino acids: SLLGHYKWEKFVYLYDTERGFSILQ AIMEAAVQNNWQVTARSVGNIKDVQ EFRRIIEEMDRRQEKRYLIDCEVER INTILEQVVILGKHSRGYHYMLANL
• Sequence Similarities: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIA3 subfamily.

Gene Information

• Gene Name: GRIA3 glutamate receptor, ionotrophic, AMPA 3 [ Homo sapiens ]
• Official Symbol: GRIA3
• Synonyms: GRIA3; glutamate receptor, ionotrophic, AMPA 3; GLUR3; glutamate receptor 3; GLURC; MRX94
• Gene ID: 2892
• mRNA Refseq: NM_000828
• Protein Refseq: NP_000819
• MIM: 305915
• Uniprot ID: P42263
• Chromosome Location: Xq25
• Pathway: Activation of AMPA receptors, organism-specific biosystem; Activation of NMDA receptor upon glutamate binding and postsynaptic events, organism-specific biosystem; Dopaminergic synapse, organism-specific biosystem; Dopaminergic synapse, conserved biosystem; Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity, organism-specific biosystem
• Function: PDZ domain binding; alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity; extracellular-glutamate-gated ion channel activity; ion channel activity; receptor activity