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Recombinant Human GRN, His-tagged

Cat.No.: GRN-26404TH
Product Overview: Recombinant full length Human Granulin with an N-terminal His-tag, 10 kDa.
Description: Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis.
Protein length: 67 amino acids
Conjugation: HIS
Molecular Weight: 10.000kDa inclusive of tags
Source: E. coli
Tissue specificity: In myelogenous leukemic cell lines of promonocytic, promyelocytic, and proerythroid lineage, in fibroblasts, and very strongly in epithelial cell lines. Present in inflammatory cells and bone marrow. Highest levels in kidney.
Form: Liquid
Purity: >90% by SDS-PAGE
Storage buffer: Preservative: NoneConstituents: 55mM Tris HCl, 150mM Sodium chloride, pH 8.2
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Sequence Similarities: Belongs to the granulin family.
Gene Name: GRN granulin [ Homo sapiens ]
Official Symbol: GRN
Synonyms: GRN; granulin; granulins; PCDGF; PGRN; progranulin;
Gene ID: 2896
mRNA Refseq: NM_002087
Protein Refseq: NP_002078
MIM: 138945
Uniprot ID: P28799
Chromosome Location: 17q21.32
Function: cytokine activity; growth factor activity;

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