Recombinant Human GRN, His-tagged
Cat.No. : | GRN-26404TH |
Product Overview : | Recombinant full length Human Granulin with an N-terminal His-tag, 10 kDa. |
- Specification
- Gene Information
- Related Products
Description : | Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis. |
Protein length : | 67 amino acids |
Conjugation : | HIS |
Molecular Weight : | 10.000kDa inclusive of tags |
Source : | E. coli |
Tissue specificity : | In myelogenous leukemic cell lines of promonocytic, promyelocytic, and proerythroid lineage, in fibroblasts, and very strongly in epithelial cell lines. Present in inflammatory cells and bone marrow. Highest levels in kidney. |
Form : | Liquid |
Purity : | >90% by SDS-PAGE |
Storage buffer : | Preservative: NoneConstituents: 55mM Tris HCl, 150mM Sodium chloride, pH 8.2 |
Storage : | Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. |
Sequence Similarities : | Belongs to the granulin family. |
Gene Name : | GRN granulin [ Homo sapiens ] |
Official Symbol : | GRN |
Synonyms : | GRN; granulin; granulins; PCDGF; PGRN; progranulin; |
Gene ID : | 2896 |
mRNA Refseq : | NM_002087 |
Protein Refseq : | NP_002078 |
MIM : | 138945 |
Uniprot ID : | P28799 |
Chromosome Location : | 17q21.32 |
Function : | cytokine activity; growth factor activity; |
Products Types
◆ Recombinant Protein | ||
GRN-1022H | Recombinant Human GRN Protein, His (Fc)-Avi-tagged | +Inquiry |
GRN-041H | Recombinant Human GRN Protein, MYC/DDK-tagged, C13 and N15-labeled | +Inquiry |
Grn-1065M | Recombinant Mouse Grn Protein, MYC/DDK-tagged | +Inquiry |
GRN-5375H | Recombinant Human GRN Protein, GST-tagged | +Inquiry |
Grn-1593R | Recombinant Rat Grn Protein, His-tagged | +Inquiry |
◆ Lysates | ||
GRN-2412MCL | Recombinant Mouse GRN cell lysate | +Inquiry |
GRN-2791HCL | Recombinant Human GRN cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
- Q&As
- Reviews
Q&As (6)
Ask a questionThere is an interaction between GRN protein and TDP-43 protein, and together they are involved in the development of neurodegenerative diseases.
GRN protein is involved in neuroprotection by regulating cell survival, apoptosis, inflammatory response and other pathways. It may work by promoting neuronal survival, suppressing inflammatory responses, and more.
Abnormal expression of GRN protein is related to neurodegenerative diseases, and detecting the expression level of GRN protein or gene mutation can help diagnose these diseases and provide reference for treatment and prognosis assessment.
The role of GRN protein in Alzheimer's disease is not fully understood, but studies have shown that it is involved in the metabolism and clearance of β-amyloid, which may have an important impact on the pathological process.
Yes, some transcription factors have been found to regulate the expression of GRN proteins, including CREB, SMAD, etc.
GRN protein plays an important role in prefrontal dementia. It is involved in the survival and maintenance of nerve cells, and its deletion or mutation may lead to degenerative loss of nerve cells.
Customer Reviews (3)
Write a reviewThe outstanding quality of proteins lies in their strong biological activity and their high purity during production, which is really rare.
Application of this protein enables researchers to conduct research in more fields and broadens the horizon of scientific research.
This protein has a short half-life, high clearance rate, and high safety and efficacy.
Ask a Question for All GRN Products
Required fields are marked with *
My Review for All GRN Products
Required fields are marked with *
Inquiry Basket