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Recombinant Human GSR protein

Cat.No.: GSR-29083TH
Product Overview: Recombinant Human GSR Purified from E.coli expressing the human Glutathione Reductase gene (44-522aa with additional 3 amino acids-GSH at N-term)
Description: Glutathione reductase (GR) is a member of pyridine nucleotide-disulfide oxidoreductases, which includes the closely related enzymes thioredoxin reductase, lipoamide dehydrogenase, trypanothione reductase and mercuric ion reductase. GR is a cytoplasmic flavoenzyme widely distributed in aerobic organisms. The dimeric protein is composed of two identical subunits, each containing 1 FAD and 1 redox-active disulfide/dithiol as components of the catalytic apparatus. It plays a role in maintaining glutathione (GSH) in its reduced form by catalyzing the reduction of glutathione disulfide (GSSG): GSSG + NADPH + H+ ⇔ 2GSH + NADP+ In most eukaryotic cells, GR maintains the ratio of [GSH]/[GSSG] elevated, and participates in several vital functions such as the detoxification of reactive oxygen species as well as protein and DNA biosynthesis.
Source: E. coli
Species: Human
Form: Lyophilized from 20mM HEPES, pH 7.5
Bio-activity: 19.4U/mg
Molecular Mass: 51.7 kDa
Purity: > 95% by SDS-PAGE
Unit Definition: One unit will reduce 1μmole of oxidized glutathione per min at pH 7.5 at 25 centigrade
Storage: Shipped at 4 centigrade. Store at -20 centigrade. After reconstitution, store at -80 centigrade and avoid frequent freeze and thaw.
Gene Name: GSR glutathione reductase [ Homo sapiens ]
Official Symbol: GSR
Synonyms: GSR; glutathione reductase; glutathione reductase, mitochondrial; GR; GRase; MGC78522;
Gene ID: 2936
mRNA Refseq: NM_000637
Protein Refseq: NP_000628
MIM: 138300
UniProt ID: P00390
Chromosome Location: 8p21.1
Pathway: Glutathione metabolism, organism-specific biosystem; Glutathione metabolism, organism-specific biosystem; Glutathione metabolism, conserved biosystem; Metabolism, organism-specific biosystem; Metabolism of nucleotides, organism-specific biosystem; Oxidative Stress, organism-specific biosystem; Selenium Pathway, organism-specific biosystem;
Function: NADP binding; electron carrier activity; flavin adenine dinucleotide binding; glutathione binding; glutathione-disulfide reductase activity; oxidoreductase activity; protein homodimerization activity;

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