Recombinant Human GTF2B, His-tagged

• Cat.No.: GTF2B-30661TH
• Product Overview: Recombinant full length Human TFIIB with N terminal His tag; 336 amino acids with tag, MWt 36.9kDa.

Specification

• Description: This gene encodes the general transcription factor IIB, one of the ubiquitous factors required for transcription initiation by RNA polymerase II. The protein localizes to the nucleus where it forms a complex (the DAB complex) with transcription factors IID and IIA. Transcription factor IIB serves as a bridge between IID, the factor which initially recognizes the promoter sequence, and RNA polymerase II.
• Conjugation: HIS
• Molecular Weight: 36.900kDa inclusive of tags
• Source: E. coli
• Form: Liquid
• Purity: >90% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 20% Glycerol, 0.1M Sodium chloride, 20mM Tris HCl, pH 8.0
• Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Sequences of amino acids: MGSSHHHHHH SSGLVPRGSH MASTSRLDAL PRVTCPNHPD AILVEDYRAG DMICPECGLV VGDRVIDVGS EWRTFSNDKA TKDPSRVGDS QNPLLSDGDL STMIGKGTGA ASFDEFGNSK YQNRRTMSSS DRAMMNAFKE ITTMADRINL PRNIVDRTNN LFKQVYEQKS LKGRANDAIA SACLYIACRQ EGVPRTFKEI CAVSRISKKE IGRCFKLILK ALETSVDLIT TGDFMSRFCS NLCLPKQVQM AATHIARKAV ELDLVPGRSP ISVAAAAIYM ASQASAEKRT QKEIGDIAGV ADVTIRQSYR LIYPRAPDLF PTDFKFDTPV DKLPQL
• Sequence Similarities: Belongs to the TFIIB family.Contains 1 TFIIB-type zinc finger.

Gene Information

• Gene Name: GTF2B general transcription factor IIB [ Homo sapiens ]
• Official Symbol: GTF2B
• Synonyms: GTF2B; general transcription factor IIB; transcription initiation factor IIB; TFIIB
• Gene ID: 2959
• mRNA Refseq: NM_001514
• Protein Refseq: NP_001505
• MIM: 189963
• Uniprot ID: Q00403
• Chromosome Location: 1p22-p21
• Pathway: Basal transcription factors, organism-specific biosystem; Basal transcription factors, conserved biosystem; Eukaryotic Transcription Initiation, organism-specific biosystem; Formation and Maturation of mRNA Transcript, organism-specific biosystem; Gene Expression, organism-specific biosystem
• Function: DNA binding; metal ion binding; protein binding; thyroid hormone receptor binding; transcription factor binding