Native Human HBA2

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Native Human HBA2

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Cat.No. : HBA2-27786TH
Product Overview : Full length native Human Haemoglobin A1c purified from Human erythrocytes; 141 amino acids, MWt 15 kDa.
Description : The human alpha globin gene cluster located on chromosome 16 spans about 30 kb and includes seven loci: 5- zeta - pseudozeta - mu - pseudoalpha-1 - alpha-2 - alpha-1 - theta - 3. The alpha-2 (HBA2) and alpha-1 (HBA1) coding sequences are identical. These genes differ slightly over the 5 untranslated regions and the introns, but they differ significantly over the 3 untranslated regions. Two alpha chains plus two beta chains constitute HbA, which in normal adult life comprises about 97% of the total hemoglobin; alpha chains combine with delta chains to constitute HbA-2, which with HbF (fetal hemoglobin) makes up the remaining 3% of adult hemoglobin. Alpha thalassemias result from deletions of each of the alpha genes as well as deletions of both HBA2 and HBA1; some nondeletion alpha thalassemias have also been reported.
Source : Human Erythrocytes
Species : Human
Form : Liquid
Molecular Mass : 15.000kDa
Protein length : 141 amino acids
Storage : Shipped on dry ice. Upon delivery aliquot and store at -20°C . Avoid freeze / thaw cycles.
Storage Buffer : Proprietary buffer formulation, pH 8.0.
Gene Name : HBA2 hemoglobin, alpha 2 [ Homo sapiens ]
Official Symbol : HBA2
Synonyms : HBA2; hemoglobin, alpha 2; hemoglobin subunit alpha; alpha globin; alpha-globin; alpha-2 globin; hemoglobin alpha chain; HBH;
Gene ID : 3040
mRNA Refseq : NM_000517
Protein Refseq : NP_000508
MIM : 141850
UniProt ID : P69905
Chromosome Location : 16p13.3
Pathway : African trypanosomiasis, organism-specific biosystem; African trypanosomiasis, conserved biosystem; Malaria, organism-specific biosystem; Malaria, conserved biosystem; Selenium Pathway, organism-specific biosystem;
Function : contributes_to haptoglobin binding; heme binding; metal ion binding; oxygen binding; oxygen transporter activity; contributes_to peroxidase activity; protein binding;

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