Native Human HBA2

• Cat.No.: HBA2-27786TH
• Product Overview: Full length native Human Haemoglobin A1c purified from Human erythrocytes; 141 amino acids, MWt 15 kDa.

Specification

• Description: The human alpha globin gene cluster located on chromosome 16 spans about 30 kb and includes seven loci: 5- zeta - pseudozeta - mu - pseudoalpha-1 - alpha-2 - alpha-1 - theta - 3. The alpha-2 (HBA2) and alpha-1 (HBA1) coding sequences are identical. These genes differ slightly over the 5 untranslated regions and the introns, but they differ significantly over the 3 untranslated regions. Two alpha chains plus two beta chains constitute HbA, which in normal adult life comprises about 97% of the total hemoglobin; alpha chains combine with delta chains to constitute HbA-2, which with HbF (fetal hemoglobin) makes up the remaining 3% of adult hemoglobin. Alpha thalassemias result from deletions of each of the alpha genes as well as deletions of both HBA2 and HBA1; some nondeletion alpha thalassemias have also been reported.
• Source: Human Erythrocytes
• Species: Human
• Form: Liquid
• Molecular Mass: 15.000kDa
• Protein length: 141 amino acids
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -20°C . Avoid freeze / thaw cycles.
• Storage Buffer: Proprietary buffer formulation, pH 8.0.

Gene Information

• Gene Name: HBA2 hemoglobin, alpha 2 [ Homo sapiens ]
• Official Symbol: HBA2
• Synonyms: HBA2; hemoglobin, alpha 2; hemoglobin subunit alpha; alpha globin; alpha-globin; alpha-2 globin; hemoglobin alpha chain; HBH
• Gene ID: 3040
• mRNA Refseq: NM_000517
• Protein Refseq: NP_000508
• MIM: 141850
• UniProt ID: P69905
• Chromosome Location: 16p13.3
• Pathway: African trypanosomiasis, organism-specific biosystem; African trypanosomiasis, conserved biosystem; Malaria, organism-specific biosystem; Malaria, conserved biosystem; Selenium Pathway, organism-specific biosystem
• Function: contributes_to haptoglobin binding; heme binding; metal ion binding; oxygen binding; oxygen transporter activity; contributes_to peroxidase activity; protein binding