"HDAC2" Related Products

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Recombinant Human HDAC2

Cat.No.: HDAC2-28264TH
Product Overview: Recombinant full length Human HDAC2 with a C-terminal proprietary tag. Expressed by baculovirus in Sf9 insect cells. Genbank Number:
Description: This gene product belongs to the histone deacetylase family. Histone deacetylases act via the formation of large multiprotein complexes, and are responsible for the deacetylation of lysine residues at the N-terminal regions of core histones (H2A, H2B, H3 and H4). This protein forms transcriptional repressor complexes by associating with many different proteins, including YY1, a mammalian zinc-finger transcription factor. Thus, it plays an important role in transcriptional regulation, cell cycle progression and developmental events. Alternative splicing results in multiple transcript variants.
Protein length: 488 amino acids
Molecular Weight: 92.000kDa inclusive of tags
Source: Baculovirus
Tissue specificity: Widely expressed; lower levels in brain and lung.
Form: Liquid
Purity: by SDS-PAGE
Storage buffer: Preservative: NoneConstituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 10mM Glutathione, 0.25mM DTT, 0.1mM EDTA, 0.1mM PMSF, pH 7.5
Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Sequence Similarities: Belongs to the histone deacetylase family. HD type 1 subfamily.
Gene Name: HDAC2 histone deacetylase 2 [ Homo sapiens ]
Official Symbol: HDAC2
Synonyms: HDAC2; histone deacetylase 2; RPD3; YAF1;
Gene ID: 3066
mRNA Refseq: NM_001527
Protein Refseq: NP_001518
MIM: 605164
Uniprot ID: Q92769
Chromosome Location: 6q21
Pathway: Cell cycle, organism-specific biosystem; Cell cycle, organism-specific biosystem; Cell cycle, conserved biosystem; Chronic myeloid leukemia, organism-specific biosystem; Chronic myeloid leukemia, conserved biosystem;
Function: NAD-dependent histone deacetylase activity (H3-K14 specific); NAD-dependent histone deacetylase activity (H3-K9 specific); NAD-dependent histone deacetylase activity (H4-K16 specific); chromatin binding; enzyme binding;

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