Recombinant Human HDAC4
Cat.No. : | HDAC4-28265TH |
Product Overview : | Recombinant fragment of Human HDAC4 with N-terminal proprietary tag, 77kDa. |
- Specification
- Gene Information
- Related Products
Description : | Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3. |
Protein length : | 473 amino acids |
Molecular Weight : | 77.000kDa inclusive of tags |
Source : | Baculovirus infected sf9 cells |
Tissue specificity : | Ubiquitous. |
Biological activity : | The Specific activity of HDAC4-28265TH was determined to be 60 RLU/min/ng. |
Form : | Liquid |
Purity : | >95% by SDS-PAGE |
Storage buffer : | Preservative: NoneConstituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 10mM Glutathione, 0.25mM DTT, 0.1mM EDTA, 0.1mM PMSF, pH 7.5 |
Storage : | Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles. |
Sequence Similarities : | Belongs to the histone deacetylase family. HD type 2 subfamily. |
Gene Name : | HDAC4 histone deacetylase 4 [ Homo sapiens ] |
Official Symbol : | HDAC4 |
Synonyms : | HDAC4; histone deacetylase 4; HA6116; HD4; HDAC 4; HDAC A; HDACA; KIAA0288; |
Gene ID : | 9759 |
mRNA Refseq : | NM_006037 |
Protein Refseq : | NP_006028 |
MIM : | 605314 |
Uniprot ID : | P56524 |
Chromosome Location : | 2q37.3 |
Pathway : | Cell cycle, organism-specific biosystem; Endochondral Ossification, organism-specific biosystem; MicroRNAs in cardiomyocyte hypertrophy, organism-specific biosystem; Signaling events mediated by HDAC Class I, organism-specific biosystem; Signaling events mediated by HDAC Class II, organism-specific biosystem; |
Function : | NAD-dependent histone deacetylase activity (H3-K14 specific); NAD-dependent histone deacetylase activity (H3-K9 specific); NAD-dependent histone deacetylase activity (H4-K16 specific); activating transcription factor binding; histone deacetylase activity; |
Products Types
◆ Recombinant Protein | ||
HDAC4-095H | Recombinant Human HDAC4 Protein, GST-tagged | +Inquiry |
HDAC4-022H | Recombinant Human HDAC4 Protein, GST-tagged | +Inquiry |
HDAC4-4645H | Recombinant Human HDAC4 Protein, GST-tagged | +Inquiry |
HDAC4-1054H | Recombinant Human HDAC4 Protein, His (Fc)-Avi-tagged | +Inquiry |
HDAC4-2793H | Recombinant Human HDAC4 protein(91-320 aa), C-His-tagged | +Inquiry |
◆ Lysates | ||
HDAC4-001HCL | Recombinant Human HDAC4 cell lysate | +Inquiry |
◆ Assay kits | ||
Kit-1740 | HDAC4 Fluorogenic Assay Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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