"HDAC4" Related Products

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Recombinant Human HDAC4, His-tagged

Cat.No.: HDAC4-28266TH
Product Overview: Recombinant fragment, corresponding to amino acids 556-1084 of Human HDAC4 with a N terminal His tag; MWt 85 kDa:
Description: Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3.
Conjugation: HIS
Source: E. coli
Tissue specificity: Ubiquitous.
Form: Lyophilised:reconstitution with 125 μl aqua dest.
Storage buffer: Preservative: NoneConstituents: 0.5% Trehalose, 6M Urea, 100mM Sodium phosphate, 10mM Sodium chloride, pH 4.5
Storage: Shipped at 4°C. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Sequences of amino acids: VQVKQEPIESDEEEAEPPREVEPGQRQPSEQELLFRQQAL LLEQQRIHQLRNYQASMEAAGIPVSFGGHRPLSRAQSS PASATFPVSVQEPPTKPRFTTGLVYDTLMLKHQCTCGS SSSHPEHAGRIQSIWSRLQETGLRGKCECIRGRKATLEEL QTVHSEAHTLLYGTNPLNRQKLDSKKLLGSLASVFVRL PCGGVGVDSDTIWNEVHSAGAARLAVGCVVELVFKVAT GELKNGFAVVRPPGHHAEESTPMGFCYFNSVAVAAKLL QQRLSVSKILIVDWDVHHGNGTQQAFYSDPSVLYMSLHRY DDGNFFPGSGAPDEVGTGPGVGFNVNMAFTGGLDPPMG DAEYLAAFRTVVMPIASEFAPDVVLVSSGFDAVEGHPT PLGGYNLSARCFGYLTKQLMGLAGGRIVLALEGGHDLTAICDASEACVSALLGNELDPLPEKVLQQRPNANAVRSMEK VMEIHSKYWRCLQRTTSTAGRSLIEAQTCENEEAETVT AMASLSVGVKPAEKRPDEEPMEEEPPL
Sequence Similarities: Belongs to the histone deacetylase family. HD type 2 subfamily.
Gene Name: HDAC4 histone deacetylase 4 [ Homo sapiens ]
Official Symbol: HDAC4
Synonyms: HDAC4; histone deacetylase 4; HA6116; HD4; HDAC 4; HDAC A; HDACA; KIAA0288;
Gene ID: 9759
mRNA Refseq: NM_006037
Protein Refseq: NP_006028
MIM: 605314
Uniprot ID: P56524
Chromosome Location: 2q37.3
Pathway: Cell cycle, organism-specific biosystem; Endochondral Ossification, organism-specific biosystem; MicroRNAs in cardiomyocyte hypertrophy, organism-specific biosystem; Signaling events mediated by HDAC Class I, organism-specific biosystem; Signaling events mediated by HDAC Class II, organism-specific biosystem;
Function: NAD-dependent histone deacetylase activity (H3-K14 specific); NAD-dependent histone deacetylase activity (H3-K9 specific); NAD-dependent histone deacetylase activity (H4-K16 specific); activating transcription factor binding; histone deacetylase activity;

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