Recombinant Human HDAC4, His-tagged
Cat.No. : | HDAC4-28266TH |
Product Overview : | Recombinant fragment, corresponding to amino acids 556-1084 of Human HDAC4 with a N terminal His tag; MWt 85 kDa: |
- Specification
- Gene Information
- Related Products
Description : | Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3. |
Conjugation : | HIS |
Source : | E. coli |
Tissue specificity : | Ubiquitous. |
Form : | Lyophilised:reconstitution with 125 μl aqua dest. |
Storage buffer : | Preservative: NoneConstituents: 0.5% Trehalose, 6M Urea, 100mM Sodium phosphate, 10mM Sodium chloride, pH 4.5 |
Storage : | Shipped at 4°C. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles. |
Sequences of amino acids : | VQVKQEPIESDEEEAEPPREVEPGQ RQPSEQELLFRQQAL LLEQQRIHQLRNYQASMEAAGIPVS FGGHRPLSRAQSS PASATFPVSVQEPPTKPRFTTGLVY DTLMLKHQCTCGS SSSHPEHAGRIQSIWSRLQETGLRG KCECIRGRKATLEEL QTVHSEAHTLLYGTNPLNRQKLDSK KLLGSLASVFVRL PCGGVGVDSDTIWNEVHSAGAARLA VGCVVELVFKVAT GELKNGFAVVRPPGHHAEESTPMGF CYFNSVAVAAKLL QQRLSVSKILIVDWDVHHGNGTQQA FYSDPSVLYMSLHRY DDGNFFPGSGAPDEVGTGPGVGFNV NMAFTGGLDPPMG DAEYLAAFRTVVMPIASEFAPDVVL VSSGFDAVEGHPT PLGGYNLSARCFGYLTKQLMGLAGG RIVLALEGGHDLTAICDASEACVSA LLGNELDPLPEKVLQQRPNANAVRS MEK VMEIHSKYWRCLQRTTSTAGRSLIE AQTCENEEAETVT AMASLSVGVKPAEKRPDEEPMEEEP PL |
Sequence Similarities : | Belongs to the histone deacetylase family. HD type 2 subfamily. |
Gene Name : | HDAC4 histone deacetylase 4 [ Homo sapiens ] |
Official Symbol : | HDAC4 |
Synonyms : | HDAC4; histone deacetylase 4; HA6116; HD4; HDAC 4; HDAC A; HDACA; KIAA0288; |
Gene ID : | 9759 |
mRNA Refseq : | NM_006037 |
Protein Refseq : | NP_006028 |
MIM : | 605314 |
Uniprot ID : | P56524 |
Chromosome Location : | 2q37.3 |
Pathway : | Cell cycle, organism-specific biosystem; Endochondral Ossification, organism-specific biosystem; MicroRNAs in cardiomyocyte hypertrophy, organism-specific biosystem; Signaling events mediated by HDAC Class I, organism-specific biosystem; Signaling events mediated by HDAC Class II, organism-specific biosystem; |
Function : | NAD-dependent histone deacetylase activity (H3-K14 specific); NAD-dependent histone deacetylase activity (H3-K9 specific); NAD-dependent histone deacetylase activity (H4-K16 specific); activating transcription factor binding; histone deacetylase activity; |
Products Types
◆ Recombinant Protein | ||
HDAC4-095H | Recombinant Human HDAC4 Protein, GST-tagged | +Inquiry |
HDAC4-1053H | Recombinant Human HDAC4 Protein, MYC/DDK-tagged | +Inquiry |
Hdac4-3369M | Recombinant Mouse Hdac4 Protein, Myc/DDK-tagged | +Inquiry |
HDAC4-4645H | Recombinant Human HDAC4 Protein, GST-tagged | +Inquiry |
HDAC4-1308H | Recombinant Human HDAC4 protein(Met612-Leu1084) | +Inquiry |
◆ Lysates | ||
HDAC4-001HCL | Recombinant Human HDAC4 cell lysate | +Inquiry |
◆ Assay kits | ||
Kit-1740 | HDAC4 Fluorogenic Assay Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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