Recombinant Human HMGB1, His-tagged
Cat.No. : | HMGB1-29332TH |
Product Overview : | Recombinant full length Human HMGB1 with an N-terminal histidine tag.M.Wt 25 kDa. |
- Specification
- Gene Information
- Related Products
Description : | High-mobility group protein B1, also known as high-mobility group protein 1 (HMG-1) and amphoterin, is a protein that in humans is encoded by the HMGB1 gene. |
Conjugation : | HIS |
Source : | E. coli |
Form : | Lyophilised:Reconstitution of 1 vial with 1 ml of water to result with solution containing 20 mM HEPES buffer, pH 7.8, 150 mM NaCl, 0.2 mM EDTA, 0.1 % TRITON X-100, 2 mg/ml leupeptin, and 0.1 mM AEBSF. |
Purity : | >90% by SDS-PAGE |
Storage buffer : | Preservative: NoneConstituents: 0.1% Triton-X-100, 2mg/ml Leupeptin, 20mM HEPES, 150mM Sodium chloride, 0.2mM EDTA, 0.1mM AEBSF, pH 7.8 |
Storage : | Store at +4°C. Aliquot and store at -20°C or -80°C when reconstituted. Avoid repeated freeze / thaw cycles. |
Sequence Similarities : | Belongs to the HMGB family.Contains 2 HMG box DNA-binding domains. |
Gene Name : | HMGB1 high mobility group box 1 [ Homo sapiens ] |
Official Symbol : | HMGB1 |
Synonyms : | HMGB1; high mobility group box 1; high mobility group (nonhistone chromosomal) protein 1 , high mobility group box 1 , HMG1; high mobility group protein B1; Amphoterin; DKFZp686A04236; high mobility group protein 1; HMG3; SBP 1; Sulfoglucuronyl carbohydr |
Gene ID : | 3146 |
mRNA Refseq : | NM_002128 |
Protein Refseq : | NP_002119 |
MIM : | 163905 |
Uniprot ID : | P09429 |
Chromosome Location : | 13q12 |
Pathway : | Activated TLR4 signalling, organism-specific biosystem; Activation of DNA fragmentation factor, organism-specific biosystem; Advanced glycosylation endproduct receptor signaling, organism-specific biosystem; Androgen Receptor Signaling Pathway, organism-specific biosystem; Apoptosis, organism-specific biosystem; |
Function : | DNA bending activity; DNA bending activity; DNA binding; RAGE receptor binding; calcium-dependent protein kinase regulator activity; |
Products Types
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HMGB1-1929R | Recombinant Rhesus Macaque HMGB1 Protein, His (Fc)-Avi-tagged | +Inquiry |
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◆ Native Protein | ||
HMGB1-8447B | Active Native Bovine HMGB1 | +Inquiry |
◆ Lysates | ||
HMGB1-2076HCL | Recombinant Human HMGB1 cell lysate | +Inquiry |
HMGB1-1677MCL | Recombinant Mouse HMGB1 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
- Q&As
- Reviews
Q&As (6)
Ask a questionThis protein can promote tumor growth, invasion and angiogenesis, and plays an important role in tumor immune evasion.
Yes, HMGB1 protein plays an important role in tumor metastasis, particularly by promoting invasion of tumor cells and migration of the hematopoietic system.
Is involved in inflammatory response, vascular damage, and thrombosis in cardiovascular disease and may be associated with myocardial ischemia-reperfusion injury.
HMGB1 protein can promote the activation, chemotaxis and inflammatory response of immune cells, and is also involved in regulating the balance of autoimmune response.
HMGB1 protein is associated with processes such as chronic inflammation and insulin resistance in diabetes and may be a potential target for treatment and prevention.
The protein is involved in pathological processes such as liver fibrosis, hepatitis, and liver cancer in liver disease and may be a target for therapeutic strategies.
Customer Reviews (3)
Write a reviewBroad storage conditions of HMGB1ins make the experimental process more stable and reliable, which provides a strong guarantee for scientific research.
I found that tHMGB1 exhibited very good stability during storage, which allowed us to perform experiments easily and obtain reliable results.
The anti-contamination ability of HMGB1 was excellent in Western blot, and the contamination problem in the experiment was avoided.
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