"HNF1B" Related Products


Recombinant Human HNF1B

Cat.No.: HNF1B-29461TH
Product Overview: Recombinant fragment of Human TCF2 with N terminal proprietary tag; Predicted MW 37.29kDa.
Description: This gene encodes a member of the homeodomain-containing superfamily of transcription factors. The protein binds to DNA as either a homodimer, or a heterodimer with the related protein hepatocyte nuclear factor 1-alpha. The gene has been shown to function in nephron development, and regulates development of the embryonic pancreas. Mutations in this gene result in renal cysts and diabetes syndrome and noninsulin-dependent diabetes mellitus, and expression of this gene is altered in some types of cancer. Multiple transcript variants encoding different isoforms have been found for this gene.
Protein length: 105 amino acids
Molecular Weight: 37.290kDa inclusive of tags
Source: Wheat germ
Form: Liquid
Purity: Proprietary Purification
Storage buffer: pH: 8.00Constituents:0.3% Glutathione, 0.79% Tris HCl
Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Sequence Similarities: Belongs to the HNF1 homeobox family.Contains 1 homeobox DNA-binding domain.
Gene Name: HNF1B HNF1 homeobox B [ Homo sapiens ]
Official Symbol: HNF1B
Synonyms: HNF1B; HNF1 homeobox B; TCF2, transcription factor 2, hepatic; LF B3; variant hepatic nuclear factor; hepatocyte nuclear factor 1-beta; HNF1beta; LFB3; MODY5; VHNF1;
Gene ID: 6928
mRNA Refseq: NM_000458
Protein Refseq: NP_000449
MIM: 189907
Uniprot ID: P35680
Chromosome Location: 17q12
Pathway: Developmental Biology, organism-specific biosystem; Maturity onset diabetes of the young, organism-specific biosystem; Maturity onset diabetes of the young, conserved biosystem; Regulation of beta-cell development, organism-specific biosystem; Regulation of gene expression in early pancreatic precursor cells, organism-specific biosystem;
Function: DNA binding; protein binding; protein heterodimerization activity; protein homodimerization activity; protein homodimerization activity;

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