Recombinant Human Fibroblast Growth Factor Receptor 2

• Cat.No.: FGFR2-488H

Specification

• Cat. No.: FGFR2-488H
• Description: FGFR2 is a member of the fibroblast growth factor receptor family which play a role in mitogenesis and differentiation. FGFR2 is a high-affinity receptor for acidic, basic and/or keratinocyte growth factor, and mutations in FGFR2 are associated with Crouzon syndrome, Pfeiffer syndrome, Craniosynostosis, Apert syndrome, Jackson-Weiss syndrome, Saethre-Chotzen syndrome, and syndromic craniosynostosis. FGFR2 is required for early postimplantation development between implantation and the formation of the egg cylinder. FGFR2 contributes to the outgrowth, differentiation, and maintenance of the inner cell mass.
• Source: Sf21 Insect Cells.
• Molecular Weight: The predicted molecular weight of Recombinant Human FGF R2α (IIIb) is Mr 66 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 100 kDa.
• State Of Matter: Lyophilized.
• Purity: > 90% by SDS Page and analyzed by silver stain.
• Endotoxin: < 0.1 ng per 1 µg as determined by the LAL method.
• Storage And Stability: This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.

Gene Information

• Gene Name: FGFR2 fibroblast growth factor receptor 2 [ Homo sapiens ]
• Synonyms: FGFR2; fibroblast growth factor receptor 2; BEK; JWS; CEK3; CFD1; ECT1; KGFR; TK14; TK25; BFR-1; CD332; K-SAM; FLJ98662; FGF receptor; OTTHUMP00000020624; OTTHUMP00000020626; soluble FGFR4 variant 4; bacteria-expressed kinase; hydroxyaryl-protein kinase; keratinocyte growth factor receptor; BEK fibroblast growth factor receptor; protein tyrosine kinase, receptor like 14; EC 2.7.10.1; Crouzon syndrome; Pfeiffer syndrome; craniofacial dysostosis 1; Jackson-Weiss syndrome; Keratinocyte growth factor receptor 2; K-SAM; CD332 antigen; BEK fibroblast growth factor receptor; FGF receptor
• Gene ID: 2263
• mRNA Refseq: NM_000141
• Protein Refseq: NP_000132
• UniProt ID: P21802
• Chromosome Location: 10q25.3-q26
• MIM: 176943
• Pathway: Endocytosis; MAPK signaling pathway; Pathways in cancer; Prostate cancer; Regulation of actin cytoskeleton
• Function: ATP binding; fibroblast growth factor receptor activity; heparin binding; nucleotide binding; protein binding; receptor activity; transferase activity

Reviews

08/24/2017

The FGFR2 protein is an outstanding product that possesses exceptional quality, making it an ideal choice for my experimental needs.

03/05/2017

What sets FGFR2 apart is the manufacturer's unparalleled technical support.

09/13/2016

The versatility of the FGFR2 protein makes it a valuable asset in my research.

Q&As

How is FGFR2 linked to developmental disorders?

Mutations in FGFR2 are associated with various developmental disorders, impacting the development of the skull, limbs, and other structures.

Can FGFR2 be targeted for personalized cancer therapy?

Yes, targeting FGFR2 mutations allows for more personalized and precise therapeutic approaches in cancer treatment.

Are there clinical trials involving FGFR2 inhibitors?

Yes, numerous clinical trials are underway to evaluate the efficacy of FGFR2 inhibitors in treating various cancers and developmental disorders.

How does FGFR2 impact wound healing?

FGFR2 is involved in the regulation of cell migration and tissue repair, contributing to the process of wound healing.

Are there any side effects associated with FGFR2 inhibitors?

Common side effects of FGFR2 inhibitors include fatigue, nausea, and hypertension, which are being studied for better management.