Active Recombinant Human HSPA8, His-tagged

• Cat.No.: HSPA8-28200TH
• Product Overview: Recombinant Human HSPA8, fussed with His tag, was expressed in E. coli

Specification

• Description: Heat shock 70 kDa protein 8 also known as heat shock cognate 71 kDa protein or Hsc70 or Hsp73 is a heat shock protein that in humans is encoded by the HSPA8 gene. As a member of the heat shock protein 70 family and a chaperone protein, it facilitates the proper folding of newly translated and misfolded proteins, as well as stabilize or degrade mutant proteins. Its functions contribute to biological processes including signal transduction, apoptosis, protein homeostasis, and cell growth and differentiation. It has been associated with an extensive number of cancers, neurodegenerative diseases, cell senescence and aging.
• Source: E. coli
• Species: Human
• Tag: His
• Form: 20mM Tris/HCl pH7.5, 1mM EDTA.
• Bio-activity: The protein has ATPase activity at the time of manufacture of 3.2μM phosphate liberated/hr/μg protein in a 200μl reaction at 37°C (pH 8) in the presence of 20ul of 1mM ATP using a Malachite Green assay.
• Molecular Mass: Molecular weight of approximately 73kDa
• Purity: >90% pure using SDS-PAGE analysis.
• Applications: ATPase Assay, WB control, Binding Assay, ELISA reference standard
• Stability: Store at -20°C; more than 1 year. Avoid freeze/ thaw cycle.
• Concentration: 2.1 mg/mL

Gene Information

• Gene Name: HSPA8 heat shock 70kDa protein 8 [ Homo sapiens ]
• Official Symbol: HSPA8
• Synonyms: LAP1; HSC54; HSC70; HSC71; HSP71; HSP73; LAP-1; NIP71; HEL-33; HSPA10; HEL-S-72p; heat shock cognate 71 kDa protein; LPS-associated protein 1; N-myristoyltransferase inhibitor protein 71; constitutive heat shock protein 70; epididymis luminal protein 33; epididymis secretory sperm binding protein Li 72p; heat shock 70kd protein 10; heat shock cognate protein 54; lipopolysaccharide-associated protein 1
• Gene ID: 3312
• mRNA Refseq: NM_006597
• Protein Refseq: NP_006588
• MIM: 600816
• UniProt ID: P11142
• Chromosome Location: 11q24.1
• Pathway: AUF1 (hnRNP D0) destabilizes mRNA, organism-specific biosystem; Antigen processing and presentation, conserved biosystem; Developmental Biology, organism-specific biosystem
• Function: ATP binding; ATPase activity; C3HC4-type RING finger domain binding