"HUS1" Related Products

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Recombinant Human HUS1, His-tagged

Cat.No.: HUS1-29414TH
Product Overview: Recombinant full length Human HUS1 with an N terminal His tag; 300 amino acids with tag, Predicted MWt 33.8 kDa.
Description: The protein encoded by this gene is a component of an evolutionarily conserved, genotoxin-activated checkpoint complex that is involved in the cell cycle arrest in response to DNA damage. This protein forms a heterotrimeric complex with checkpoint proteins RAD9 and RAD1. In response to DNA damage, the trimeric complex interacts with another protein complex consisting of checkpoint protein RAD17 and four small subunits of the replication factor C (RFC), which loads the combined complex onto the chromatin. The DNA damage induced chromatin binding has been shown to depend on the activation of the checkpoint kinase ATM, and is thought to be an early checkpoint signaling event. Alternative splicing results in multiple transcript variants.
Protein length: 280 amino acids
Conjugation: HIS
Molecular Weight: 33.800kDa inclusive of tags
Source: E. coli
Tissue specificity: Ubiquitous.
Form: Liquid
Purity: >95% by SDS-PAGE
Storage buffer: Preservative: NoneConstituents: 40% Glycerol, 20mM Tris HCl, 100mM Sodium chloride, pH 8.0
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Sequences of amino acids: MGSSHHHHHHSSGLVPRGSHMKFRAKIVDGACLNHFTRISNMIAKLAKTCTLRISPDKLNFILCDKLANGGVSMWCELEQENFFNEFQMEGVSAENNEIYLELTSENLSRALKTAQNARALKIKLTNKHFPCLTVSVELLSMSSSSRIVTHDIPIKVIPRKLWKDLQEPVVPDPDVSIYLPVLKTMKSVVEKMKNISNHLVIEANLDGELNLKIETELVCVTTHFKDLGNPPLASESTHEDRNVEHMAEVHIDIRKLLQFLAGQQVNPTKALCNIVNNKMVHFDLLHEDVSLQYFIPALS
Sequence Similarities: Belongs to the HUS1 family.
Gene Name: HUS1 HUS1 checkpoint homolog (S. pombe) [ Homo sapiens ]
Official Symbol: HUS1
Synonyms: HUS1; HUS1 checkpoint homolog (S. pombe); HUS1 (S. pombe) checkpoint homolog; checkpoint protein HUS1; hus1+ like protein;
Gene ID: 3364
mRNA Refseq: NM_004507
Protein Refseq: NP_004498
MIM: 603760
Uniprot ID: O60921
Chromosome Location: 7p13-p12
Pathway: Activation of ATR in response to replication stress, organism-specific biosystem; Cell Cycle Checkpoints, organism-specific biosystem; G2/M Checkpoints, organism-specific biosystem; Regulation of Telomerase, organism-specific biosystem;
Function: protein binding; protein serine/threonine kinase activity;

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