"IL17A" Related Products

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Recombinant Human IL17A, Fc-tagged

Cat.No.: IL17A-28212TH
Product Overview: Recombinant full length Human IL17 fused at the C-terminus to the Fc portion of Human IgG1; MWt 45 kDa .
Description: The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis.
Protein length: 155 amino acids
Conjugation: Fc
Molecular Weight: 45.000kDa inclusive of tags
Source: HEK 293 cells
Tissue specificity: Restricted to activated memory T-cells.
Form: Liquid
Purity: >90% by SDS-PAGE
Storage buffer: Preservative: NoneConstituents: PBS
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Sequence Similarities: Belongs to the IL-17 family.
Gene Name: IL17A interleukin 17A [ Homo sapiens ]
Official Symbol: IL17A
Synonyms: IL17A; interleukin 17A; CTLA8, IL17, interleukin 17 (cytotoxic T lymphocyte associated serine esterase 8); interleukin-17A; cytotoxic T lymphocyte associated protein 8; IL 17; IL 17A;
Gene ID: 3605
mRNA Refseq: NM_002190
Protein Refseq: NP_002181
MIM: 603149
Uniprot ID: Q16552
Chromosome Location: 6p12
Pathway: Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; IL23-mediated signaling events, organism-specific biosystem; IL27-mediated signaling events, organism-specific biosystem; Rheumatoid arthritis, organism-specific biosystem;
Function: cytokine activity;

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