Recombinant Human IL2RB, Fc-tagged

• Cat.No.: IL2RB-29776TH
• Product Overview: Recombinant fragment, corresponding to amino acids 27-237 of Human IL2 Receptor beta fused to the Fc region of human IgG1 expressed in modified human 293 cells.

Specification

• Description: The interleukin 2 receptor, which is involved in T cell-mediated immune responses, is present in 3 forms with respect to ability to bind interleukin 2. The low affinity form is a monomer of the alpha subunit and is not involved in signal transduction. The intermediate affinity form consists of an alpha/beta subunit heterodimer, while the high affinity form consists of an alpha/beta/gamma subunit heterotrimer. Both the intermediate and high affinity forms of the receptor are involved in receptor-mediated endocytosis and transduction of mitogenic signals from interleukin 2. The protein encoded by this gene represents the beta subunit and is a type I membrane protein.
• Conjugation: Fc
• Biological activity: IL2RB-29776TH bound to protein A sepharose beads is able to pull down its ligand, IL2.
• Form: Lyophilised:It is recommended that 0.5 ml of sterile phosphate-buffered saline be added to the vial.Following reconstitution short-term storage at 4°C is recommended, and longer-term storage of aliquots at -18 to -20°C. Repeated freeze thawing is not reco
• Purity: >95% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 10% Trehalose, 1% Human serum albumin
• Storage: Store at +4°C.
• Sequences of amino acids: Theoretical Sequence:AVNGTSQFTCFYNSRANISCVWSQD GALQ DTSCQVHAWPDRRRWNQTCELLPVS QASWACNLILGAP DSQKLTTVDIVTLRVLCREGVRWRV MAIQDFKPFENLR LMAPISLQVVHVETHRCNISWEISQ ASHYFERHLEFEARTLSPGHTWEEA PLLTLKQKQEWICLETLTPDTQYEF QVR VKPLQGEFTTWSPWSQPLAFRTKPA ALGIPKVDKKVEP KSCDKTHTCPPCPAPELLGGPSVFL FPPKPKDTLMISR TPEVTCVVVDVSHEDPEVKFNWYVD GVEVHNAKTKPRE EQYNSTYRVVSVLTVLHQDWLNGKE YKCKVSNKALPAPIE KTISKAKGQPREPQVYTLPPSRDEL TKNQVSLTCLVKG FYPSDIAVEWESNGQPENNYKTTPP VLDSDGSFFLYSK LTVDKSRWQQGNVFSCSVMHEALHN HYTQKSLSLSPGK

Gene Information

• Gene Name: IL2RB interleukin 2 receptor, beta [ Homo sapiens ]
• Official Symbol: IL2RB
• Synonyms: IL2RB; interleukin 2 receptor, beta; IL15RB, interleukin 15 receptor, beta; interleukin-2 receptor subunit beta; CD122
• Gene ID: 3560
• mRNA Refseq: NM_000878
• Protein Refseq: NP_000869
• MIM: 146710
• Uniprot ID: P14784
• Chromosome Location: 22q13
• Pathway: Cytokine Signaling in Immune system, organism-specific biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Downstream signaling in naive CD8+ T cells, organism-specific biosystem; Endocytosis, organism-specific biosystem
• Function: interleukin-2 binding; interleukin-2 receptor activity; contributes_to interleukin-2 receptor activity; receptor activity