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Active Recombinant Human IL33 protein, FLAG-tagged

Cat.No. : IL33-29791TH
Product Overview : Recombinant Human IL33(aa 112-270) fused with FLAG tag at C-terminal was expressed in HEK293.
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  • Gene Information
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Description : Interleukin-33 (IL-33; HF-NEV; IL-1F11), a member of the IL-1 family of cytokines, is expressed by many cell types following pro-inflammatory stimulation and is thought to be released on cell lysis. The 30kDa human IL33 is converted by CASP1 to a 18kDa protein. IL33 binds to and signals through ST2 (IL1R1) and its stimulation recruits MYD88, IRAK, IRAK4, and TRAF6, followed by phosphorylation of ERK1 (MAPK3)/ERK2 (MAPK1), p38 (MAPK14), and JNK. The ability of IL-33 to target numerous immune cell types, like Th2-like cells, mast cells, and B1 cells, and to induce cytokine and chemokine production underlines its potential in influencing the outcome of a wide range of diseases, such as arthritis, asthma, atopic allergy & anaphylaxis, cardiovascular disease/atherosclerosis, nervous system diseases, and sepsis.
Source : HEK293
Species : Human
Tag : FLAG
Form : Liquid. 0.2μm-filtered solution in PBS, pH 7.2.
Bio-activity : Activates human ST2-dependent NF-κB pathway.
Molecular Mass : ~23kDa (SDS-PAGE)
Endotoxin : <0.1EU/μg purified protein (LAL test; Lonza).
Purity : ≥90% (SDS-PAGE)
Stability : Working aliquots are stable for up to 3 months when stored at -20 centigrade.
Storage : Short Term Storage +4 centigrade;Long Term Storage -20 centigrade;After opening, prepare aliquots and store at -20 centigrade. Avoid freeze/thaw cycles.
Concentration : 1mg/ml
Gene Name : IL33 interleukin 33 [ Homo sapiens ]
Official Symbol : IL33
Synonyms : IL33; interleukin 33; C9orf26, chromosome 9 open reading frame 26 (NF HEV); interleukin-33; DKFZp586H0523; DVS27; DVS27 related protein; IL1F11; interleukin 1 family; member 11; NF HEV; nuclear factor for high endothelial venules; IL-33; IL-1F11; DVS27-related protein; interleukin-1 family member 11; nuclear factor from high endothelial venules; NF-HEV; NFEHEV; C9orf26; RP11-575C20.2;
Gene ID : 90865
mRNA Refseq : NM_001199640
Protein Refseq : NP_001186569
MIM : 608678
UniProt ID : O95760
Chromosome Location : 9p24.1
Pathway : Cytosolic DNA-sensing pathway, organism-specific biosystem; Cytosolic DNA-sensing pathway, conserved biosystem; Influenza A, organism-specific biosystem; Influenza A, conserved biosystem;
Function : cytokine activity; protein binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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Which immune cells can recombinant IL33 be used to detect? 05/28/2022

It can be used to detect immune cells such as macrophages and dendritic cells.

In what research fields can recombinant IL33 be applied? 09/24/2020

This protein applied in immunology, drug research, life science and other fields.

What is the action mechanism of IL33? 08/09/2020

Regulates the activity of immune cells by binding to receptors to stimulate the production of inflammatory factors such as interferon and TNF-α.

Besides treating asthma and hay fever, what other diseases can be treated with IL33? 07/28/2019

IL33 can also be used to treat a variety of inflammatory diseases, such as inflammatory bowel disease, psoriasis and so on.

How to prepare IL33? 03/25/2019

The preparation of IL33 requires first cloning the IL33 gene into the expression vector, and then the expression vector is expressed and purified in the cell culture medium.

How long does it take to treat asthma with IL33? 01/10/2019

Treating asthma with recombinant IL33 takes several weeks to several months to be effective, depending on the severity of the condition and the individual patient.

Customer Reviews (3)

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Reviews
10/16/2021

    Good solubility and is easy to operate and purify.

    05/03/2021

      Effectively mimics the function of the target protein in vitro.

      03/18/2020

        IL33 has a wide range of applications in the field of scientific research and is suitable for a variety of experimental design and research purposes.

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