Recombinant Human Insulin-Like Growth Factor 1 Receptor

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Recombinant Human Insulin-Like Growth Factor 1 Receptor

IGF1R Related Products

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Cat. No. : IGF1R-1631H
Description : Insulin-like Growth Factor 1 (IGF-1) Receptor is a transmembrane tyrosine kinase that is frequently overexpressed by tumours, and mediates proliferation and apoptosis protection.IGF-1 receptor may be a central regulator of mammalian lifespan2 and when activated, it results in survival and proliferation in mitosis-competent cells, and growth (hypertrophy) in tissues such as skeletal muscle and cardiac muscle. IGF1R is now an attractive anti-cancer treatment target.
Source : Mammalian cells
State Of Matter : Lyophilized.
Purity : >95% by SDS Page and analyzed by silver stain.
Endotoxin : <1.0 EU/µg as determined by the LAL method.
Molecular Weight : The predicted molecular weight of Recombinant Human IGF-I sR is Mr 81, 23, 104 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 150, 120, 48 kDa.
Storage And Stability : This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
The first three domains of insulin-like growth factor 1 receptor. PDB rendering based on 1igr. :

Gene Name : IGF1R insulin-like growth factor 1 receptor [ Homo sapiens ]
Synonyms : IGF1R; insulin-like growth factor 1 receptor; IGFR; CD221; IGFIR; JTK13; MGC18216; MGC142170; MGC142172; soluble IGF1R variant 1; soluble IGF1R variant 2; EC 2.7.10.1; CD221; IGF-I receptor; CD221 antigen; Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain
Gene ID : 3480
mRNA Refseq : NM_000875
Protein Refseq : NP_000866
MIM : 147370
UniProt ID : P08069
Chromosome Location : 15q26.3
Pathway : Adherens junction; Colorectal cancer; Endocytosis; Focal adhesion; Glioma; Long-term depression; Melanoma; Pathways in cancer; Prostate cancer
Function : ATP binding; identical protein binding; insulin binding; insulin receptor binding; insulin receptor substrate binding; insulin-like growth factor I binding; insulin-like growth factor receptor activity; nucleotide binding; phosphoinositide 3-kinase binding; receptor activity; transferase activity
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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