Recombinant Human IRF6

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Recombinant Human IRF6

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Cat.No. : IRF6-28727TH
Product Overview : Recombinant fragment of Human IRF6 with N-terminal proprietary tag. Predicted MW 36.63kDa.
Description : This gene encodes a member of the interferon regulatory transcription factor (IRF) family. Family members share a highly-conserved N-terminal helix-turn-helix DNA-binding domain and a less conserved C-terminal protein-binding domain. The encoded protein may be a transcriptional activator. Mutations in this gene can cause van der Woude syndrome and popliteal pterygium syndrome. Mutations in this gene are also associated with non-syndromic orofacial cleft type 6. Alternate splicing results in multiple transcript variants.
Protein length : 100 amino acids
Molecular Weight : 36.630kDa inclusive of tags
Source : Wheat germ
Tissue specificity : Expressed in normal mammary epithelial cells. Expression is reduced or absent in breast carcinomas.
Form : Liquid
Purity : Proprietary Purification
Storage buffer : pH: 8.00Constituents:0.3% Glutathione, 0.79% Tris HCl
Storage : Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Sequences of amino acids : PFEIYLCFGE EWPDGKPLER KLILVQVIPV VARMIYEMFS GDFTRSFDSG SVRLQISTPD IKDNIVAQLK QLYRILQTQE SWQPMQPTPS MQLPPALPPQ
Sequence Similarities : Belongs to the IRF family.Contains 1 IRF tryptophan pentad repeat DNA-binding domain.
Gene Name : IRF6 interferon regulatory factor 6 [ Homo sapiens ]
Official Symbol : IRF6
Synonyms : IRF6; interferon regulatory factor 6; LPS, Van der Woude syndrome , VWS; OFC6; VWS1;
Gene ID : 3664
mRNA Refseq : NM_001206696
Protein Refseq : NP_001193625
MIM : 607199
Uniprot ID : O14896
Chromosome Location : 1q32.2-q32.3
Pathway : Apoptosis, organism-specific biosystem; Cytokine Signaling in Immune system, organism-specific biosystem; Immune System, organism-specific biosystem; Interferon Signaling, organism-specific biosystem; Interferon alpha/beta signaling, organism-specific biosystem;
Function : DNA binding; protein binding; regulatory region DNA binding; sequence-specific DNA binding transcription factor activity;
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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