Recombinant Human ISL1

• Cat.No.: ISL1-28841TH
• Product Overview: Recombinant fragment corresponding to amino acids 1-100 of Human Islet 1 refolded to soluble form; 100 amino acids, Predicted MWt 11.5 kDa.

Specification

• Description: This gene encodes a member of the LIM/homeodomain family of transcription factors. The encoded protein binds to the enhancer region of the insulin gene, among others, and may play an important role in regulating insulin gene expression. The encoded protein is central to the development of pancreatic cell lineages and may also be required for motor neuron generation. Mutations in this gene have been associated with maturity-onset diabetes of the young.
• Protein length: 100 amino acids
• Molecular Weight: 11.500kDa
• Source: E. coli
• Tissue specificity: Expressed in subsets of neurons of the adrenal medulla and dorsal root ganglion, inner nuclear and ganglion cell layers in the retina, the pineal and some regions of the brain.
• Form: Liquid
• Purity: >90% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: high-salt-PBS, 8.1mM Dibasic monohydrogen sodium phosphate, 500mM Sodium chloride, 2.7mM Potassium chloride, 1.5mM Monobasic dihydrogen potassium phosphate, pH 7.4
• Storage: Aliquot and store at -80°C. Avoid repeated freeze / thaw cycles.
• Sequence Similarities: Contains 1 homeobox DNA-binding domain.Contains 2 LIM zinc-binding domains.

Gene Information

• Gene Name: ISL1 ISL LIM homeobox 1 [ Homo sapiens ]
• Official Symbol: ISL1
• Synonyms: ISL1; ISL LIM homeobox 1; ISL1 transcription factor, LIM/homeodomain, (islet 1); insulin gene enhancer protein ISL-1; Isl 1; ISLET1
• Gene ID: 3670
• mRNA Refseq: NM_002202
• Protein Refseq: NP_002193
• MIM: 600366
• Uniprot ID: P61371
• Chromosome Location: 5q11.2
• Pathway: Heart Development, organism-specific biosystem; Incretin Synthesis, Secretion, and Inactivation, organism-specific biosystem; Integration of energy metabolism, organism-specific biosystem; Metabolism, organism-specific biosystem; Regulation of Insulin Secretion, organism-specific biosystem
• Function: RNA polymerase II activating transcription factor binding; RNA polymerase II transcription coactivator activity; bHLH transcription factor binding; chromatin binding; enhancer sequence-specific DNA binding