"ISL1" Related Products


Recombinant Human ISL1

Cat.No.: ISL1-28841TH
Product Overview: Recombinant fragment corresponding to amino acids 1-100 of Human Islet 1 refolded to soluble form; 100 amino acids, Predicted MWt 11.5 kDa.
Description: This gene encodes a member of the LIM/homeodomain family of transcription factors. The encoded protein binds to the enhancer region of the insulin gene, among others, and may play an important role in regulating insulin gene expression. The encoded protein is central to the development of pancreatic cell lineages and may also be required for motor neuron generation. Mutations in this gene have been associated with maturity-onset diabetes of the young.
Protein length: 100 amino acids
Molecular Weight: 11.500kDa
Source: E. coli
Tissue specificity: Expressed in subsets of neurons of the adrenal medulla and dorsal root ganglion, inner nuclear and ganglion cell layers in the retina, the pineal and some regions of the brain.
Form: Liquid
Purity: >90% by SDS-PAGE
Storage buffer: Preservative: NoneConstituents: high-salt-PBS, 8.1mM Dibasic monohydrogen sodium phosphate, 500mM Sodium chloride, 2.7mM Potassium chloride, 1.5mM Monobasic dihydrogen potassium phosphate, pH 7.4
Storage: Aliquot and store at -80°C. Avoid repeated freeze / thaw cycles.
Sequence Similarities: Contains 1 homeobox DNA-binding domain.Contains 2 LIM zinc-binding domains.
Gene Name: ISL1 ISL LIM homeobox 1 [ Homo sapiens ]
Official Symbol: ISL1
Synonyms: ISL1; ISL LIM homeobox 1; ISL1 transcription factor, LIM/homeodomain, (islet 1); insulin gene enhancer protein ISL-1; Isl 1; ISLET1;
Gene ID: 3670
mRNA Refseq: NM_002202
Protein Refseq: NP_002193
MIM: 600366
Uniprot ID: P61371
Chromosome Location: 5q11.2
Pathway: Heart Development, organism-specific biosystem; Incretin Synthesis, Secretion, and Inactivation, organism-specific biosystem; Integration of energy metabolism, organism-specific biosystem; Metabolism, organism-specific biosystem; Regulation of Insulin Secretion, organism-specific biosystem;
Function: RNA polymerase II activating transcription factor binding; RNA polymerase II transcription coactivator activity; bHLH transcription factor binding; chromatin binding; enhancer sequence-specific DNA binding;

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