Recombinant Human JUP protein, GST-tagged

• Cat.No.: JUP-27307TH
• Product Overview: Recombinant Human JUP（1 a.a. - 745 a.a.）fused with GST tag at N-terminal was expressed in Wheat Germ.

Specification

• Description: This gene encodes a major cytoplasmic protein which is the only known constituent common to submembranous plaques of both desmosomes and intermediate junctions. This protein forms distinct complexes with cadherins and desmosomal cadherins and is a member of the catenin family since it contains a distinct repeating amino acid motif called the armadillo repeat. Mutation in this gene has been associated with Naxos disease. Alternative splicing occurs in this gene; however, not all transcripts have been fully described.
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Form: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
• Molecular Mass: 107.69 kDa
• AA Sequence: MEVMNLMEQPIKVTEWQQTYTYDSG IHSGANTCVPSVSSKGIMEEDEACG RQYTLKKTTTYTQGVPPSQGDLEYQ MSTTARAKRVREAMCPGVSGEDSSL LLATQVEGQATNLQRLAEPSQLLKS AIVHLINYQDDAELATRALPELTKL LNDEDPVVVTKAAMIVNQLSKKEAS RRALMGSPQLVAAVVRTMQNTSDLD TARCTTSILHNLSHHREGLLAIFKS GGIPALVRMLSSPVESVLFYAITTL HNLLLYQEGAKMAVRLADGLQKMVP LLNKNNPKFLAITTDCLQLLAYGNQ ESKLIILANGGPQALVQIMRNYSYE KLLWTTSRVLKVLSVCPSNKPAIVE AGGMQALGKHLTSNSPRLVQNCLWT LRNLSDVATKQEGLESVLKILVNQL SVDDVNVLTCATGTLSNLTCNNSKN KTLVTQNSGVEALIHAILRAGDKDD ITEPAVCALRHLTSRHPEAEMAQNS VRLNYGIPAIVKLLNQPNQWPLVKA TIGLIRNLALCPANHAPLQEAAVIP RLVQLLVKAHQDAQRHVAAGTQQPY TDGVRMEEIVEGCTGALHILARDPM NRMEIFRLNTIPLFVQPLYSSVENI QRVAAGALCELAQDKEAADAIDAEG ASAPLMELLHSRNEGTATYAAAVLF RISEDKNPDYRKRVSVELTNSLFKH DPAAWEAAQSMIPINEPYGDDLDAT YRPMYSSDVPLDPLEMHMDMDGDYP IDTYSDGLRPPYPTADHMLA
• Applications: Enzyme-linked Immunoabsorbent Assay; Western Blot (Recombinant protein); Antibody Production; Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.

Gene Information

• Gene Name: JUP junction plakoglobin [ Homo sapiens ]
• Official Symbol: JUP
• Synonyms: JUP; junction plakoglobin; catenin (cadherin associated protein), gamma 80kDa , CTNNG; DP3; DPIII; PDGB; PKGB; catenin gamma; desmoplakin-3; gamma-catenin; desmoplakin III; catenin (cadherin-associated protein), gamma 80kDa; catenin (cadherin-associated protein), gamma (80kD); CTNNG; ARVD12
• Gene ID: 3728
• mRNA Refseq: NM_002230
• Protein Refseq: NP_002221
• MIM: 173325
• UniProt ID: P14923
• Chromosome Location: 17q21
• Pathway: Acute myeloid leukemia, organism-specific biosystem; Acute myeloid leukemia, conserved biosystem; Adherens junctions interactions, organism-specific biosystem; Arf6 trafficking events, organism-specific biosystem; Arrhythmogenic right ventricular cardiomyopathy (ARVC), organism-specific biosystem; Arrhythmogenic right ventricular cardiomyopathy (ARVC), conserved biosystem; Cell junction organization, organism-specific biosystem
• Function: RPTP-like protein binding; alpha-catenin binding; cadherin binding; protein binding; protein homodimerization activity; protein kinase binding; protein phosphatase binding; structural constituent of cell wall; structural molecule activity; transcription coactivator activity