Recombinant Human KCNJ2

• Cat.No.: KCNJ2-27881TH
• Product Overview: Recombinant fragment of Human Kir2.1 (amino acids 328-427) with N terminal proprietary tag; Predicted MWt 36.63 kDa including the tag.

Specification

• Description: Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Mutations in this gene have been associated with Andersen syndrome, which is characterized by periodic paralysis, cardiac arrhythmias, and dysmorphic features.
• Protein length: 100 amino acids
• Molecular Weight: 36.630kDa inclusive of tags
• Source: Wheat germ
• Tissue specificity: Heart, brain, placenta, lung, skeletal muscle, and kidney. Diffusely distributed throughout the brain.
• Form: Liquid
• Purity: Proprietary Purification
• Storage buffer: pH: 8.00Constituents:0.79% Tris HCl, 0.3% Glutathione
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequences of amino acids: PVLFEEKHYYKVDYSRFHKTYEVPN TPLCSARDLAEKKYILSNANSFCYE NEVALTSKEEDDSENGVPESTSTDT PPDIDLHNQASVPLEPRPLRRESEI
• Sequence Similarities: Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ2 subfamily.

Gene Information

• Gene Name: KCNJ2 potassium inwardly-rectifying channel, subfamily J, member 2 [ Homo sapiens ]
• Official Symbol: KCNJ2
• Synonyms: KCNJ2; potassium inwardly-rectifying channel, subfamily J, member 2; inward rectifier potassium channel 2; IRK1; Kir2.1
• Gene ID: 3759
• mRNA Refseq: NM_000891
• Protein Refseq: NP_000882
• MIM: 600681
• Uniprot ID: P63252
• Chromosome Location: 17q24.3
• Pathway: Activation of G protein gated Potassium channels, organism-specific biosystem; Activation of GABAB receptors, organism-specific biosystem; Cholinergic synapse, organism-specific biosystem; Classical Kir channels, organism-specific biosystem; G protein gated Potassium channels, organism-specific biosystem
• Function: inward rectifier potassium channel activity; voltage-gated ion channel activity