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Native Human KLK1

Cat.No.: KLK1-29685TH
Product Overview: Full length native Human Kallikrein 1 from Human plasma, 86-88kDa.
Description: Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. This protein is functionally conserved in its capacity to release the vasoactive peptide, Lys-bradykinin, from low molecular weight kininogen.
Tissue specificity: Isoform 2 is expressed in pancreas, salivary glands, kidney, colon, prostate gland, testis, spleen and the colon adenocarcinoma cell line T84.
Biological activity: Activity: 15 units per mg. One unit is defined as the amount of enzyme that hydrolyzes one umole of D-Pro-Phe-Arg-pNA per minute at 25°C, pH 7.8.
Form: Liquid
Purity: >95% by SDS-PAGE
Storage buffer: Preservative: NoneConstituents: 20mM Tris HCl, 100mM Sodium chloride, pH 7.8
Storage: Shipped on dry ice. Upon delivery aliquot and store at -20oC. Avoid freeze / thaw cycles.
Sequence Similarities: Belongs to the peptidase S1 family. Kallikrein subfamily.Contains 1 peptidase S1 domain.
Gene Name: KLK1 kallikrein 1 [ Homo sapiens ]
Official Symbol: KLK1
Synonyms: KLK1; kallikrein 1; kallikrein 1, renal/pancreas/salivary; kallikrein-1; Klk6;
Gene ID: 3816
mRNA Refseq: NM_002257
Protein Refseq: NP_002248
Uniprot ID: P06870
Chromosome Location: 19q13.3
Pathway: Blood Clotting Cascade, organism-specific biosystem; Endocrine and other factor-regulated calcium reabsorption, organism-specific biosystem; Endocrine and other factor-regulated calcium reabsorption, conserved biosystem;
Function: peptidase activity; serine-type endopeptidase activity;

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