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Native Human KLK1

Cat.No. : KLK1-29685TH
Product Overview : Full length native Human Kallikrein 1 from Human plasma, 86-88kDa.
  • Specification
  • Gene Information
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Description : Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. This protein is functionally conserved in its capacity to release the vasoactive peptide, Lys-bradykinin, from low molecular weight kininogen.
Tissue specificity : Isoform 2 is expressed in pancreas, salivary glands, kidney, colon, prostate gland, testis, spleen and the colon adenocarcinoma cell line T84.
Biological activity : Activity: 15 units per mg. One unit is defined as the amount of enzyme that hydrolyzes one umole of D-Pro-Phe-Arg-pNA per minute at 25°C, pH 7.8.
Form : Liquid
Purity : >95% by SDS-PAGE
Storage buffer : Preservative: NoneConstituents: 20mM Tris HCl, 100mM Sodium chloride, pH 7.8
Storage : Shipped on dry ice. Upon delivery aliquot and store at -20oC. Avoid freeze / thaw cycles.
Sequence Similarities : Belongs to the peptidase S1 family. Kallikrein subfamily.Contains 1 peptidase S1 domain.
Gene Name : KLK1 kallikrein 1 [ Homo sapiens ]
Official Symbol : KLK1
Synonyms : KLK1; kallikrein 1; kallikrein 1, renal/pancreas/salivary; kallikrein-1; Klk6;
Gene ID : 3816
mRNA Refseq : NM_002257
Protein Refseq : NP_002248
Uniprot ID : P06870
Chromosome Location : 19q13.3
Pathway : Blood Clotting Cascade, organism-specific biosystem; Endocrine and other factor-regulated calcium reabsorption, organism-specific biosystem; Endocrine and other factor-regulated calcium reabsorption, conserved biosystem;
Function : peptidase activity; serine-type endopeptidase activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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How is KLK1 involved in coagulation and fibrinolysis? 08/10/2022

KLK1 participates in the regulation of blood clotting and fibrinolysis by influencing the activation of certain coagulation factors and promoting fibrinolysis.

How does KLK1 impact renal function? 06/06/2020

KLK1 contributes to renal function by promoting vasodilation in the renal blood vessels and influencing sodium and water excretion, which can be beneficial in kidney diseases.

Is KLK1 associated with cancer? 03/26/2020

Some studies suggest that KLK1 may be involved in cancer progression, but the relationship is complex and not fully understood. Further research is needed.

Are there any clinical applications of KLK1 in inflammatory conditions? 05/18/2019

Some studies suggest that KLK1-based therapies may have potential in managing inflammatory conditions, but more research is needed for conclusive evidence.

Are there any KLK1-based therapies for cancer? 02/21/2016

The potential use of KLK1 in cancer therapy is an area of investigation, but no specific KLK1-based cancer therapies have been established yet.

Customer Reviews (3)

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Reviews
04/24/2019

    Whether measuring analyte concentrations, screening for specific interactions, or monitoring immune responses, this protein's exceptional performance in ELISA experiments is truly commendable.

    06/30/2018

      Its high quality, reliability, and exceptional performance make it an excellent choice for a wide range of experimental applications.

      12/12/2017

        This strong track record of excellence further attests to the KLK1 protein's capability to meet the rigorous demands of research projects.

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