Native Human KLK1
Cat.No. : | KLK1-29685TH |
Product Overview : | Full length native Human Kallikrein 1 from Human plasma, 86-88kDa. |
- Specification
- Gene Information
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Description : | Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. This protein is functionally conserved in its capacity to release the vasoactive peptide, Lys-bradykinin, from low molecular weight kininogen. |
Tissue specificity : | Isoform 2 is expressed in pancreas, salivary glands, kidney, colon, prostate gland, testis, spleen and the colon adenocarcinoma cell line T84. |
Biological activity : | Activity: 15 units per mg. One unit is defined as the amount of enzyme that hydrolyzes one umole of D-Pro-Phe-Arg-pNA per minute at 25°C, pH 7.8. |
Form : | Liquid |
Purity : | >95% by SDS-PAGE |
Storage buffer : | Preservative: NoneConstituents: 20mM Tris HCl, 100mM Sodium chloride, pH 7.8 |
Storage : | Shipped on dry ice. Upon delivery aliquot and store at -20oC. Avoid freeze / thaw cycles. |
Sequence Similarities : | Belongs to the peptidase S1 family. Kallikrein subfamily.Contains 1 peptidase S1 domain. |
Gene Name : | KLK1 kallikrein 1 [ Homo sapiens ] |
Official Symbol : | KLK1 |
Synonyms : | KLK1; kallikrein 1; kallikrein 1, renal/pancreas/salivary; kallikrein-1; Klk6; |
Gene ID : | 3816 |
mRNA Refseq : | NM_002257 |
Protein Refseq : | NP_002248 |
Uniprot ID : | P06870 |
Chromosome Location : | 19q13.3 |
Pathway : | Blood Clotting Cascade, organism-specific biosystem; Endocrine and other factor-regulated calcium reabsorption, organism-specific biosystem; Endocrine and other factor-regulated calcium reabsorption, conserved biosystem; |
Function : | peptidase activity; serine-type endopeptidase activity; |
Products Types
◆ Recombinant Protein | ||
KLK1-389C | Recombinant Cynomolgus Monkey KLK1 Protein, His (Fc)-Avi-tagged | +Inquiry |
KLK1-605H | Recombinant Human KLK1 Protein, GST/His-tagged | +Inquiry |
KLK1-074H | Recombinant Human KLK1 Protein, His-tagged | +Inquiry |
KLK1-3228H | Recombinant Human KLK1 Protein, His (Fc)-Avi-tagged | +Inquiry |
KLK1-2944R | Recombinant Rat KLK1 Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
KLK1-743MCL | Recombinant Mouse KLK1 cell lysate | +Inquiry |
KLK1-2901HCL | Recombinant Human KLK1 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionKLK1 participates in the regulation of blood clotting and fibrinolysis by influencing the activation of certain coagulation factors and promoting fibrinolysis.
KLK1 contributes to renal function by promoting vasodilation in the renal blood vessels and influencing sodium and water excretion, which can be beneficial in kidney diseases.
Some studies suggest that KLK1 may be involved in cancer progression, but the relationship is complex and not fully understood. Further research is needed.
Some studies suggest that KLK1-based therapies may have potential in managing inflammatory conditions, but more research is needed for conclusive evidence.
The potential use of KLK1 in cancer therapy is an area of investigation, but no specific KLK1-based cancer therapies have been established yet.
Customer Reviews (3)
Write a reviewWhether measuring analyte concentrations, screening for specific interactions, or monitoring immune responses, this protein's exceptional performance in ELISA experiments is truly commendable.
Its high quality, reliability, and exceptional performance make it an excellent choice for a wide range of experimental applications.
This strong track record of excellence further attests to the KLK1 protein's capability to meet the rigorous demands of research projects.
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