Native Human KNG1


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Native Human KNG1

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Cat.No. : KNG1-29146TH
Product Overview : Full length native Human LMW Kininogen purified from Human Plasma; MWt 65 kDa.
Description : This gene uses alternative splicing to generate two different proteins- high molecular weight kininogen (HMWK) and low molecular weight kininogen (LMWK). HMWK is essential for blood coagulation and assembly of the kallikrein-kinin system. Also, bradykinin, a peptide causing numerous physiological effects, is released from HMWK. In contrast to HMWK, LMWK is not involved in blood coagulation. Three transcript variants encoding different isoforms have been found for this gene.
Source : Human Plasma
Species : Human
Form : Lyophilised
Molecular Mass : 65 kDa
Purity : >95% by SDS-PAGE
Storage : Shipped at 4°C . Store at -20°C .
Storage Buffer : Preservative: NoneConstituents: 200mM Sodium chloride, 10mM Sodium acetate, pH 5.5
Gene Name : KNG1 kininogen 1 [ Homo sapiens ]
Official Symbol : KNG1
Synonyms : KNG1; kininogen 1; BDK, kininogen , KNG; kininogen-1; alpha 2 thiol proteinase inhibitor; bradykinin; HMWK; fitzgerald factor; high molecular weight kininogen; alpha-2-thiol proteinase inhibitor; williams-Fitzgerald-Flaujeac factor; BDK; KNG;
Gene ID : 3827
mRNA Refseq : NM_000893
Protein Refseq : NP_000884
MIM : 612358
UniProt ID : P01042
Chromosome Location : 3q21-qter
Pathway : ACE Inhibitor Pathway, organism-specific biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; Complement and Coagulation Cascades, organism-specific biosystem; Complement and coagulation cascades, organism-specific biosystem; Complement and coagulation cascades, conserved biosystem; Formation of Fibrin Clot (Clotting Cascade), organism-specific biosystem; G alpha (i) signalling events, organism-specific biosystem;
Function : cysteine-type endopeptidase inhibitor activity; heparin binding; peptidase inhibitor activity; receptor binding; zinc ion binding;

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