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Recombinant Human KRAS

Cat.No.: KRAS-29908TH
Product Overview: Recombinant full length Human cK Ras; 188 amino acids, 21.4kDa.
Description: This gene, a Kirsten ras oncogene homolog from the mammalian ras gene family, encodes a protein that is a member of the small GTPase superfamily. A single amino acid substitution is responsible for an activating mutation. The transforming protein that results is implicated in various malignancies, including lung adenocarcinoma, mucinous adenoma, ductal carcinoma of the pancreas and colorectal carcinoma. Alternative splicing leads to variants encoding two isoforms that differ in the C-terminal region.
Source: E. coli
Form: Liquid
Purity: >95% by SDS-PAGE
Storage buffer: Preservative: NoneConstituents: 64mM Tris HCl, 5mM DTE (1, 4-Dithioerythritol), 10mM Magnesium chloride, pH 7.2
Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Sequence Similarities: Belongs to the small GTPase superfamily. Ras family.
Gene Name: KRAS v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog [ Homo sapiens ]
Official Symbol: KRAS
Synonyms: KRAS; v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog; KRAS2, v Ki ras2 Kirsten rat sarcoma 2 viral oncogene homolog; GTPase KRas; KRAS1;
Gene ID: 3845
mRNA Refseq: NM_004985
Protein Refseq: NP_004976
MIM: 190070
Uniprot ID: P01116
Chromosome Location: 12p12.1
Pathway: ARMS-mediated activation, organism-specific biosystem; Acute myeloid leukemia, organism-specific biosystem; Acute myeloid leukemia, conserved biosystem; Aldosterone-regulated sodium reabsorption, organism-specific biosystem; Aldosterone-regulated sodium reabsorption, conserved biosystem;
Function: GDP binding; GMP binding; GTP binding; GTPase activity; LRR domain binding;

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