Recombinant Human L1CAM, His-tagged

• Cat.No.: L1CAM-26864TH
• Product Overview: Recombinant fragment, corresponding to amino acids 605-1065 of Human L1CAM with an N-terminal His tag; MWt 53 kDa.

Specification

• Description: The protein encoded by this gene is an axonal glycoprotein belonging to the immunoglobulin supergene family. The ectodomain, consisting of several immunoglobulin-like domains and fibronectin-like repeats (type III), is linked via a single transmembrane sequence to a conserved cytoplasmic domain. This cell adhesion molecule plays an important role in nervous system development, including neuronal migration and differentiation. Mutations in the gene cause three X-linked neurological syndromes known by the acronym CRASH (corpus callosum hypoplasia, retardation, aphasia, spastic paraplegia and hydrocephalus). Alternative splicing of a neuron-specific exon is thought to be functionally relevant.
• Conjugation: HIS
• Source: E. coli
• Form: Lyophilised:Reconstitute with 58 μl aqua dest
• Storage buffer: Preservative: NoneConstituents: 0.5% Trehalose, 6M Urea, 100mM Sodium phosphate, 10mM Sodium chloride, pH 4.5
• Storage: Shipped at 4°C. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequences of amino acids: (Amino acid sequence (Sequence determined by 5 Sequencing))QLLVVGSPGPVPRLVLSDLHLLTQS Q VRVSWSPAEDHNAPIEKYDIEFEDK EMAPEKWYSLGKV PGNQTSTTLKLSPYVHYTFRVTAIN KYGPGEPSPVSETVVTPEAAPEKNP VDVKGEGNETTNMVITWKPLRWMDW NAP QVQYRVQWRPQGTRGPWQEQIVSDP FLVVSNTSTFVPY EIKVQAVNSQGKGPEPQVTIGYSGE DYPQAIPELEGIE ILNSSAVLVKWRPVDLAQVKGHLRG YNVTYWREGSQRK HSKRHIHKDHVVVPANTTSVILSGL RPYSSYHLEVQAFNG RGSGPASEFTFSTPEGVPGHPEALH LECQSNTSLLLRW QPPLSHNGVLTGYVLSYHPLDEGGK GQLSFNLRDPELR THNLTDLSPHLRYRFQLQATTKEGP GEAIVREGGTMAL SGISDFGNISATAGENYSVVSWVPK EGQCNFRFHILFKAL GEEKGGASLSP
• Sequence Similarities: Belongs to the immunoglobulin superfamily. L1/neurofascin/NgCAM family.Contains 5 fibronectin type-III domains.Contains 6 Ig-like C2-type (immunoglobulin-like) domains.

Gene Information

• Gene Name: L1CAM L1 cell adhesion molecule [ Homo sapiens ]
• Official Symbol: L1CAM
• Synonyms: L1CAM; L1 cell adhesion molecule; antigen identified by monoclonal R1 , HSAS, HSAS1, MASA, MIC5, S10, SPG1; neural cell adhesion molecule L1; CD171
• Gene ID: 3897
• mRNA Refseq: NM_000425
• Protein Refseq: NP_000416
• MIM: 308840
• Uniprot ID: P32004
• Chromosome Location: Xq28
• Pathway: Axon guidance, organism-specific biosystem; Axon guidance, conserved biosystem; Axon guidance, organism-specific biosystem; Basigin interactions, organism-specific biosystem; Cell adhesion molecules (CAMs), organism-specific biosystem
• Function: PDZ domain binding; identical protein binding; integrin binding; protein self-association; sialic acid binding