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Recombinant Human LAMA2 protein, GST-tagged

Cat.No. : LAMA2-27944TH
Product Overview : Recombinant Human LAMA2(3013 a.a. - 3122 a.a.) fussed with GST tag at N-terminal was expressed in E. coli.
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  • Gene Information
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Description : Laminin, an extracellular protein, is a major component of the basement membrane. It is thought to mediate the attachment, migration, and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. It is composed of three subunits, alpha, beta, and gamma, which are bound to each other by disulfide bonds into a cross-shaped molecule. This gene encodes the alpha 2 chain, which constitutes one of the subunits of laminin 2 (merosin) and laminin 4 (s-merosin). Mutations in this gene have been identified as the cause of congenital merosin-deficient muscular dystrophy. Two transcript variants encoding different proteins have been found for this gene.
Source : Wheat Germ
Species : Human
Tag : GST
Form : 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Molecular Mass : 37.84 kDa
AA Sequence : DAGVPGHLCDGQWHKVTANKIKHRI ELTVDGNQVEAQSPNPASTSADTND PVFVGGFPDDLKQFGLTTSIPFRGC IRSLKLTKGTGKPLEVNFAKALELR GVQPVSCPAN
Applications : Enzyme-linked Immunoabsorbent Assay; Western Blot (Recombinant protein); Antibody Production; Protein Array
Notes : Best use within three months from the date of receipt of this protein.
Storage : Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
Gene Name : LAMA2 laminin, alpha 2 [ Homo sapiens ]
Official Symbol : LAMA2
Synonyms : LAMA2; laminin, alpha 2; LAMM; laminin subunit alpha-2; congenital muscular dystrophy; merosin; laminin M chain; merosin heavy chain; laminin-2 subunit alpha; laminin-4 subunit alpha; laminin-12 subunit alpha;
Gene ID : 3908
mRNA Refseq : NM_000426
Protein Refseq : NP_000417
MIM : 156225
UniProt ID : P24043
Chromosome Location : 6q22-q23
Pathway : Alpha6-Beta4 Integrin Signaling Pathway, organism-specific biosystem; Amoebiasis, organism-specific biosystem; Amoebiasis, conserved biosystem; Arrhythmogenic right ventricular cardiomyopathy (ARVC), organism-specific biosystem; Arrhythmogenic right ventricular cardiomyopathy (ARVC), conserved biosystem; Dilated cardiomyopathy, organism-specific biosystem; Dilated cardiomyopathy, conserved biosystem;
Function : receptor binding; structural molecule activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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How do I measure the expression level of LAMA2 protein? 07/28/2023

The expression level of LAMA2 protein can be detected by a variety of methods, such as western blotting, immunofluorescence staining, PCR, etc. These methods can help us understand the expression of LAMA2 protein in different tissues and cells, as well as how it changes under different physiological or pathological conditions.

What is the expression pattern of LAMA2 protein? 04/23/2023

The expression pattern of LAMA2 protein may be tissue-specific, and expression levels may vary in different tissues. Its expression pattern may be affected by a variety of factors, including gene regulation, transcription factors, etc.

What diseases are associated with the abnormal expression of LAMA2 protein?The abnormal expression of LAMA2 01/29/2022

Protein may be related to a variety of diseases, such as hereditary muscular dystrophy, cardiomyopathy, etc. The occurrence of these diseases may be related to mutations or abnormal expression of the LAMA2 gene, resulting in abnormal extracellular matrix and destruction of tissue structure.

What are the effects of mutations or modifications in the LAMA2 protein on organisms? 08/29/2021

Mutations or modifications of the LAMA2 protein may affect its function and thus affect the organism. The specific effects may vary depending on the type and location of the mutation or modification, which may lead to abnormalities in the tissue structure and the occurrence of disease.

What is the function of the LAMA2 protein? 08/26/2021

The main function of the LAMA2 protein may be that it is a component of the extracellular matrix and is involved in maintaining tissue structure and stability. It may exert these functions through interactions with cell surface receptors or other matrix components.

How does LAMA2 protein interact with other proteins? 09/12/2020

The LAMA2 protein may interact with other proteins to fulfill its function. These interactions may involve multiple types of protein-protein interactions, such as the binding of integrin receptors to LAMA2. Understanding these interactions can help unravel the mechanism of action of the LAMA2 protein in cells.

Customer Reviews (3)

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Reviews
12/04/2022

    LAMA2 has a wide range of applications and is suitable for a wide range of biological experiments.

    10/22/2021

      It is very qualitative, and it can maintain its structural and functional stability even after a lot of use, which shows its excellent quality and reliability.

      06/07/2021

        With high safety and high expression levels, it is ideal for laboratory and real-world applications.

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