Recombinant Human LATS2

• Cat.No.: LATS2-28502TH
• Product Overview: Recombinant fragment, corresponding to amino acids 480-1088 of Human LATS2, expressed by baculovirus in Sf9 insect cells using an N-terminal tag, 98kDa.

Specification

• Description: This gene encodes a serine/threonine protein kinase belonging to the LATS tumor suppressor family. The protein localizes to centrosomes during interphase, and early and late metaphase. It interacts with the centrosomal proteins aurora-A and ajuba and is required for accumulation of gamma-tubulin and spindle formation at the onset of mitosis. It also interacts with a negative regulator of p53 and may function in a positive feedback loop with p53 that responds to cytoskeleton damage. Additionally, it can function as a co-repressor of androgen-responsive gene expression.
• Tissue specificity: Expressed at high levels in heart and skeletal muscle and at lower levels in all other tissues examined.
• Form: Liquid
• Storage buffer: Preservative: NoneConstituents: 25% Glycerol, 50mM Sodium chloride, 50mM Tris HCl, 0.25mM DTT, 0.1mM PMSF, pH 7.5
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequence Similarities: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.Contains 1 AGC-kinase C-terminal domain.Contains 1 protein kinase domain.Contains 1 UBA domain.

Gene Information

• Gene Name: LATS2 LATS, large tumor suppressor, homolog 2 (Drosophila) [ Homo sapiens ]
• Official Symbol: LATS2
• Synonyms: LATS2; LATS, large tumor suppressor, homolog 2 (Drosophila); LATS (large tumor suppressor, Drosophila) homolog 2; serine/threonine-protein kinase LATS2
• Gene ID: 26524
• mRNA Refseq: NM_014572
• Protein Refseq: NP_055387
• MIM: 604861
• Uniprot ID: Q9NRM7
• Chromosome Location: 13q11-q12
• Pathway: Coregulation of Androgen receptor activity, organism-specific biosystem
• Function: ATP binding; metal ion binding; nucleotide binding; protein binding; protein serine/threonine kinase activity