Recombinant Human LIAS, His-tagged

• Cat.No.: LIAS-27755TH
• Product Overview: Recombinant full length protein, corresponding to amino acids 1-372 of Human LIAS, with N terminal His tag; 372 amino acids, 43kDa.

Specification

• Description: The protein encoded by this gene belongs to the biotin and lipoic acid synthetases family. It localizes in mitochondrion and plays an important role in alpha-(+)-lipoic acid synthesis. It may also function in the sulfur insertion chemistry in lipoate biosynthesis. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified.
• Conjugation: HIS
• Source: E. coli
• Form: Lyophilised:Reconstitution with 129 μl aqua dest.
• Storage buffer: Preservative: NoneConstituents: 0.5% Trehalose, 6M Urea, 100mM Sodium phosphate, 10mM Sodium chloride, pH 4.5
• Storage: Shipped at 4°C. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequences of amino acids: MSLRCGDAARTLGPRVFGRYFCSPVRPLSSLPDKKKELLQ NGPDLQDFVSGDLADRSTWDEYKGNLKRQKGERLRLPP WLKTEIPMGKNYNKLKNTLRNLNLHTVCEEARCPNIGE CWGGGEYATATATIMLMGDTCTRGCRFCSVKTARNPPP LDASEPYNTAKAIAEWGLDYVVLTSVDRDDMPDGGAEH IAKTVSYLKERNPKILVECLTPDFRGDLKAIEKVALSGLD VYAHNVETVPELQSKVRDPRANFDQSLRVLKHAKKVQP DVISKTSIMLGLGENDEQVYATMKALREADVDCLTLGQ YMQPTRRHLKVEEYITPEKFKYWEKVGNELGFHYTASG PLVRSSYKAGEFFLKNLVAKRKTKDL

Gene Information

• Gene Name: LIAS lipoic acid synthetase [ Homo sapiens ]
• Official Symbol: LIAS
• Synonyms: LIAS; lipoic acid synthetase; lipoyl synthase, mitochondrial; LAS
• Gene ID: 11019
• mRNA Refseq: NM_006859
• Protein Refseq: NP_006850
• MIM: 607031
• Uniprot ID: O43766
• Chromosome Location: 4p14
• Pathway: Lipoic acid metabolism, organism-specific biosystem; Lipoic acid metabolism, conserved biosystem; Metabolic pathways, organism-specific biosystem
• Function: 4 iron, 4 sulfur cluster binding; lipoate synthase activity; metal ion binding; transferase activity