Recombinant Human LRP5
Cat.No. : | LRP5-29428TH |
Product Overview : | Recombinant fragment corresponding to amino acids 41-130 of Human LRP5 protein with an N terminal proprietary tag; 35.53 kDa inclusive of tag. |
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- Gene Information
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Description : | This gene encodes a transmembrane low-density lipoprotein receptor that binds and internalizes ligands in the process of receptor-mediated endocytosis. This protein also acts as a co-receptor with Frizzled protein family members for transducing signals by Wnt proteins and was originally cloned on the basis of its association with type 1 diabetes mellitus in humans. This protein plays a key role in skeletal homeostasis and many bone density related diseases are caused by mutations in this gene. Mutations in this gene also cause familial exudative vitreoretinopathy. |
Protein length : | 90 amino acids |
Molecular Weight : | 35.530kDa inclusive of tags |
Source : | Wheat germ |
Tissue specificity : | Widely expressed, with the highest level of expression in the liver. |
Form : | Liquid |
Purity : | Proprietary Purification |
Storage buffer : | pH: 8.00Constituents:0.03% Glutathione, 0.79% Tris HCl |
Storage : | Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles. |
Sequences of amino acids : | RDVRLVDAGGVKLESTIVVSGLEDA AAVDFQFSKGAVYWTDVSEEAIKQT YLNQTGAAVQNVVISGLVSPDGLAC DWVGKKLYWTDSETN |
Sequence Similarities : | Belongs to the LDLR family.Contains 4 EGF-like domains.Contains 3 LDL-receptor class A domains.Contains 20 LDL-receptor class B repeats. |
Gene Name : | LRP5 low density lipoprotein receptor-related protein 5 [ Homo sapiens ] |
Official Symbol : | LRP5 |
Synonyms : | LRP5; low density lipoprotein receptor-related protein 5; EVR1, exudative vitreoretinopathy 1 , LRP7, OPPG, osteoporosis pseudoglioma syndrome; low-density lipoprotein receptor-related protein 5; BMND1; HBM; LR3; OPS; |
Gene ID : | 4041 |
mRNA Refseq : | NM_002335 |
Protein Refseq : | NP_002326 |
MIM : | 603506 |
Uniprot ID : | O75197 |
Chromosome Location : | 11q13.4 |
Pathway : | MicroRNAs in cardiomyocyte hypertrophy, organism-specific biosystem; N-cadherin signaling events, organism-specific biosystem; Wnt Signaling Pathway NetPath, organism-specific biosystem; Wnt Signaling Pathway and Pluripotency, organism-specific biosystem; Wnt signaling network, organism-specific biosystem; |
Function : | Wnt-activated receptor activity; Wnt-protein binding; coreceptor activity; protein binding; receptor activity; |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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