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Recombinant Human LRP5

Cat.No. : LRP5-29428TH
Product Overview : Recombinant fragment corresponding to amino acids 41-130 of Human LRP5 protein with an N terminal proprietary tag; 35.53 kDa inclusive of tag.
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Description : This gene encodes a transmembrane low-density lipoprotein receptor that binds and internalizes ligands in the process of receptor-mediated endocytosis. This protein also acts as a co-receptor with Frizzled protein family members for transducing signals by Wnt proteins and was originally cloned on the basis of its association with type 1 diabetes mellitus in humans. This protein plays a key role in skeletal homeostasis and many bone density related diseases are caused by mutations in this gene. Mutations in this gene also cause familial exudative vitreoretinopathy.
Protein length : 90 amino acids
Molecular Weight : 35.530kDa inclusive of tags
Source : Wheat germ
Tissue specificity : Widely expressed, with the highest level of expression in the liver.
Form : Liquid
Purity : Proprietary Purification
Storage buffer : pH: 8.00Constituents:0.03% Glutathione, 0.79% Tris HCl
Storage : Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Sequences of amino acids : RDVRLVDAGGVKLESTIVVSGLEDA AAVDFQFSKGAVYWTDVSEEAIKQT YLNQTGAAVQNVVISGLVSPDGLAC DWVGKKLYWTDSETN
Sequence Similarities : Belongs to the LDLR family.Contains 4 EGF-like domains.Contains 3 LDL-receptor class A domains.Contains 20 LDL-receptor class B repeats.
Gene Name : LRP5 low density lipoprotein receptor-related protein 5 [ Homo sapiens ]
Official Symbol : LRP5
Synonyms : LRP5; low density lipoprotein receptor-related protein 5; EVR1, exudative vitreoretinopathy 1 , LRP7, OPPG, osteoporosis pseudoglioma syndrome; low-density lipoprotein receptor-related protein 5; BMND1; HBM; LR3; OPS;
Gene ID : 4041
mRNA Refseq : NM_002335
Protein Refseq : NP_002326
MIM : 603506
Uniprot ID : O75197
Chromosome Location : 11q13.4
Pathway : MicroRNAs in cardiomyocyte hypertrophy, organism-specific biosystem; N-cadherin signaling events, organism-specific biosystem; Wnt Signaling Pathway NetPath, organism-specific biosystem; Wnt Signaling Pathway and Pluripotency, organism-specific biosystem; Wnt signaling network, organism-specific biosystem;
Function : Wnt-activated receptor activity; Wnt-protein binding; coreceptor activity; protein binding; receptor activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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