"MET" Related Products

Recombinant Human MET

Cat.No.: MET-28602TH
Product Overview: Recombinant fragment of Human Met , mutated at Methionine 1250 with a Threonine, with N-terminal proprietary tag, 81kDa inclusive of tag.
Description: The proto-oncogene MET product is the hepatocyte growth factor receptor and encodes tyrosine-kinase activity. The primary single chain precursor protein is post-translationally cleaved to produce the alpha and beta subunits, which are disulfide linked to form the mature receptor. Various mutations in the MET gene are associated with papillary renal carcinoma. Two transcript variants encoding different isoforms have been found for this gene.
Protein length: 435 amino acids
Molecular Weight: 81.000kDa inclusive of tags
Source: Baculovirus infected sf9 cells
Biological activity: Specific activity of MET-28602TH was determined to be 185 nmol/min/mg as per activity assay protocol.
Form: Liquid
Purity: Proprietary Purification
Storage buffer: pH: 7.50Constituents:0.79% Tris buffered saline, 0.88% Sodium chloride, 0.003% EDTA, 0.003% DTT, 0.002% PMSF, 25% Glycerol
Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Sequence Similarities: Belongs to the protein kinase superfamily. Tyr protein kinase family.Contains 3 IPT/TIG domains.Contains 1 protein kinase domain.Contains 1 Sema domain.
Gene Name: MET met proto-oncogene (hepatocyte growth factor receptor) [ Homo sapiens ]
Official Symbol: MET
Synonyms: MET; met proto-oncogene (hepatocyte growth factor receptor); hepatocyte growth factor receptor; HGFR; RCCP2;
Gene ID: 4233
mRNA Refseq: NM_000245
Protein Refseq: NP_000236
MIM: 164860
Uniprot ID: P08581
Chromosome Location: 7q31
Pathway: Adherens junction, organism-specific biosystem; Adherens junction, conserved biosystem; Alpha6-Beta4 Integrin Signaling Pathway, organism-specific biosystem; Arf6 signaling events, organism-specific biosystem; Axon guidance, organism-specific biosystem;
Function: ATP binding; hepatocyte growth factor-activated receptor activity; nucleotide binding; protein binding; protein tyrosine kinase activity;

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