Native Human MMP7

• Cat.No.: MMP7-28205TH
• Product Overview: Full length MMP7 enzyme purified from transfected human kidney cells.

Specification

• Description: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades proteoglycans, fibronectin, elastin and casein and differs from most MMP family members in that it lacks a conserved C-terminal protein domain. The enzyme is involved in wound healing, and studies in mice suggest that it regulates the activity of defensins in intestinal mucosa. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.
• Form: Liquid
• Storage buffer: The enzyme is supplied as a mixture of the zymogen and active enzyme, in:Preservative: 0.01% Sodium AzideConstituents: 50% Glycerol, 0.025% Brij 35, 5mM Calcium chloride, 250mM Sodium chloride, 10 mM MES, pH 5.0
• Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
• Sequence Similarities: Belongs to the peptidase M10A family.

Gene Information

• Gene Name: MMP7 matrix metallopeptidase 7 (matrilysin, uterine) [ Homo sapiens ]
• Official Symbol: MMP7
• Synonyms: MMP7; matrix metallopeptidase 7 (matrilysin, uterine); matrix metalloproteinase 7 (matrilysin, uterine) , MPSL1; matrilysin; PUMP 1
• Gene ID: 4316
• mRNA Refseq: NM_002423
• Protein Refseq: NP_002414
• MIM: 178990
• Uniprot ID: P09237
• Chromosome Location: 11q21-q22
• Pathway: Alpha6-Beta4 Integrin Signaling Pathway, organism-specific biosystem; Matrix Metalloproteinases, organism-specific biosystem; Syndecan-1-mediated signaling events, organism-specific biosystem; Wnt Signaling Pathway and Pluripotency, organism-specific biosystem; Wnt signaling pathway, organism-specific biosystem
• Function: metal ion binding; metalloendopeptidase activity; peptidase activity; zinc ion binding