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Recombinant Human MTPN, His-tagged

Cat.No.: MTPN-28770TH
Product Overview: Recombinant full length Human Myotrophin with a N terminal His tag. 138 amino acids with a predicted MWt 15 kDa including tag.
Description: The transcript produced from this gene is bi-cistronic and can encode both myotrophin and leucine zipper protein 6. The myotrophin protein is associated with cardiac hypertrophy, where it is involved in the conversion of NFkappa B p50-p65 heterodimers to p50-p50 and p65-p65 homodimers. This protein also has a potential function in cerebellar morphogenesis, and it may be involved in the differentiation of cerebellar neurons, particularly of granule cells. A cryptic ORF at the 3 end of this transcript uses a novel internal ribosome entry site and a non-AUG translation initiation codon to produce leucine zipper protein 6, a 6.4 kDa tumor antigen that is associated with myeloproliferative disease.
Protein length: 118 amino acids
Conjugation: HIS
Molecular Weight: 15.000kDa inclusive of tags
Source: E. coli
Tissue specificity: Ubiquitous.
Form: Liquid
Purity: >90% by SDS-PAGE
Storage buffer: pH: 8.00Constituents:0.24% Tris, 10% Glycerol
Storage: Please see Notes section
Sequences of amino acids: MGSSHHHHHH SSGLVPRGSH MCDKEFMWAL KNGDLDEVKD YVAKGEDVNR TLEGGRKPLH YAADCGQLEI LEFLLLKGAD INAPDKHHIT PLLSAVYEGH VSCVKLLLSK GADKTVKGPD GLTAFEATDN QAIKALLQ
Sequence Similarities: Belongs to the myotrophin family.Contains 3 ANK repeats.
Gene Name: MTPN myotrophin [ Homo sapiens ]
Official Symbol: MTPN
Synonyms: MTPN; myotrophin; GCDP; granule cell differentiation protein; MYOTROPHIN; V 1;
Gene ID: 136319
mRNA Refseq: NM_145808
Protein Refseq: NP_665807
MIM: 606484
Uniprot ID: P58546
Chromosome Location: 7q33-q35

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