Recombinant Human NCOR1, FLAG-tagged

• Cat.No.: NCOR1-28430TH
• Product Overview: Recombinant full length human Nuclear Receptor Corepressor NCoR with DDDDK tag expressed in Baculovirus system; amino acids 1-2440, 270kDa.

Specification

• Description: This gene encodes a protein that mediates ligand-independent transcription repression of thyroid-hormone and retinoic-acid receptors by promoting chromatin condensation and preventing access of the transcription machinery. It is part of a complex which also includes histone deacetylases and transcriptional regulators similar to the yeast protein Sin3p. This gene is located between the Charcot-Marie-Tooth and Smith-Magenis syndrome critical regions on chromosome 17. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 17 and 20.
• Conjugation: FLAG
• Biological activity: NCOR1-28430TH has been tested for deacetylation activity in vitro in the presence of HDAC3.
• Form: Liquid
• Purity: >95% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 20% Glycerol, 20mM Tris Cl, 100mM Potassium chloride, 1mM DTT, 0.2mM EDTA, pH 8.0
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequence Similarities: Belongs to the N-CoR nuclear receptor corepressors family.Contains 2 SANT domains.

Gene Information

• Gene Name: NCOR1 nuclear receptor corepressor 1 [ Homo sapiens ]
• Official Symbol: NCOR1
• Synonyms: NCOR1; nuclear receptor corepressor 1; nuclear receptor co repressor 1; hCIT529I10; hN CoR; KIAA1047; MGC104216; N CoR; thyroid hormone and retinoic acid receptor associated corepressor 1; TRAC1
• Gene ID: 9611
• mRNA Refseq: NM_001190438
• Protein Refseq: NP_001177367
• MIM: 600849
• Uniprot ID: O75376
• Chromosome Location: 17p11.2
• Pathway: Adipogenesis, organism-specific biosystem; BMAL1:CLOCK/NPAS2 Activates Gene Expression, organism-specific biosystem; C-MYB transcription factor network, organism-specific biosystem; Circadian Clock, organism-specific biosystem; Delta-Notch Signaling Pathway, organism-specific biosystem
• Function: histone deacetylase binding; histone deacetylase regulator activity; protein binding; retinoid X receptor binding; sequence-specific DNA binding