||Recombinant full length human Nuclear Receptor Corepressor NCoR with DDDDK tag expressed in Baculovirus system; amino acids 1-2440, 270kDa.
||This gene encodes a protein that mediates ligand-independent transcription repression of thyroid-hormone and retinoic-acid receptors by promoting chromatin condensation and preventing access of the transcription machinery. It is part of a complex which also includes histone deacetylases and transcriptional regulators similar to the yeast protein Sin3p. This gene is located between the Charcot-Marie-Tooth and Smith-Magenis syndrome critical regions on chromosome 17. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 17 and 20.
||NCOR1-28430TH has been tested for deacetylation activity in vitro in the presence of HDAC3.
||>95% by SDS-PAGE
||Preservative: NoneConstituents: 20% Glycerol, 20mM Tris Cl, 100mM Potassium chloride, 1mM DTT, 0.2mM EDTA, pH 8.0
||Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
||Belongs to the N-CoR nuclear receptor corepressors family.Contains 2 SANT domains.