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Recombinant Human PDGFRB

Cat. No.: PDGFRB-1675H
Product Overview: Recombinant Human platelet-derived growth factor receptor, beta polypeptide was expressed inNSO Cells.The DNA sequence encoding the extracellular domain of human PDGF Rβ (aa residues 1 - 530) was fused to the Fc region of human IgG1 (containing ENIEGR added at the amino-terminus and 6 histidine residues added at the carboxy-terminus of the IgG1).
Description: Platelet-derived growth factor receptor-β (PDGFRβ) is a well-characterized plasma membrane receptor with endogeneous tyrosine kinase activity, which is autophosphorylated in response to binding of dimeric platelet-derived growth factor (PDGF) ligand. PDGFRβ mediates signaling important for the proliferation, migration, and survival of mesenchymal cells. PDGFRβ is found in all cell types and is activated in breast carcinoma cells and indicate a possible role of the receptor in breast cancerogenesis.
Source: NSO cells.
Molecular Weight: The predicted molecular weight of Recombinant Human PDGF Rβ is 84 kDa. However, the actual molecular weight as observed by migration on SDS Page is 150 kDa.
State Of Matter: Lyophilized.
Formulation: 0.2 µm filtered and lyophilized from PBS.
Purity: >97% by SDS Page and analyzed by silver stain.
Endotoxin: <1.0 EU/µg as determined by the LAL method.
Biological Activity: The biological activity of Human PDGF Rβ was determined by its ability to inhibit the PDGF-BB induced 3H-thymidine incorporation in the NR6R-3T3 fibroblast cell-line (Raines, E.W. et al., 1985, Methods Enzymol. 109:749). The ED50 for this effect is typically 1 - 3 μg/ml in the presence of 4 ng/ml rhPDGF-BB.
Storage: This lyophilized protein is stable for six to twelve months when stored desiccated at -20℃ to -70℃. After aseptic reconstitution, this protein may be stored at 2℃ to 8℃ for one month or at -20℃ to -70℃ in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Gene Name: PDGFRB platelet-derived growth factor receptor, beta polypeptide [ Homo sapiens ]
Synonyms: PDGFRB; platelet-derived growth factor receptor, beta polypeptide; JTK12; PDGFR; CD140B; PDGFR1; platelet-derived growth factor receptor beta; PDGF-R-beta; CD140 antigen-like family member B; EC 2.7.10.1; CD140b; PDGF-R-beta; CD140b antigen; soluble PDGFRb variant 1
Gene ID: 5159
mRNA Refseq: NM_002609
Protein Refseq: NP_002600
MIM: 173410
UniProt ID: P09619
Chromosome Location: 5q33.1
Pathway: Calcium signaling pathway; Colorectal cancer; Cytokine-cytokine receptor interaction; Focal adhesion; Gap junction; Glioma; MAPK signaling pathway; Melanoma; Pathways in cancer; Prostate cancer; Regulation of actin cytoskeleton
Function: ATP binding; nucleotide binding; platelet activating factor receptor activity; platelet-derived growth factor beta-receptor activity; platelet-derived growth factor receptor binding; receptor activity; transferase activity; vascular endothelial growth factor receptor activity

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