Recombinant Human NFKBIA, His-tagged

• Cat.No.: NFKBIA-28232TH
• Product Overview: Recombinant full length Human IKB alpha with N terminal His tag; 337 amino acids with tag, Predicted MWt 37.7 kDa.

Specification

• Description: This gene encodes a member of the NF-kappa-B inhibitor family, which contain multiple ankrin repeat domains. The encoded protein interacts with REL dimers to inhibit NF-kappa-B/REL complexes which are involved in inflammatory responses. The encoded protein moves between the cytoplasm and the nucleus via a nuclear localization signal and CRM1-mediated nuclear export. Mutations in this gene have been found in ectodermal dysplasia anhidrotic with T-cell immunodeficiency autosomal dominant disease.
• Protein length: 317 amino acids
• Conjugation: HIS
• Molecular Weight: 37.700kDa inclusive of tags
• Source: E. coli
• Form: Liquid
• Purity: >90% by SDS-PAGE
• Storage buffer: pH: 8.00Constituents:0.32% Tris HCl, 0.02% DTT, 20% Glycerol, 0.58% Sodium chloride
• Storage: Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Sequences of amino acids: MGSSHHHHHHSSGLVPRGSHMFQAAERPQEWAMEGPRDGL KKERLLDDRHDSGLDSMKDEEYEQMVKELQEIRLEPQE VPRGSEPWKQQLTEDGDSFLHLAIIHEEKALTMEVIRQVK GDLAFLNFQNNLQQTPLHLAVITNQPEIAEALLGAGCD PELRDFRGNTPLHLACEQGCLASVGVLTQSCTTPHLHSIL KATNYNGHTCLHLASIHGYLGIVELLVSLGADVNAQEP CNGRTALHLAVDLQNPDLVSLLLKCGADVNRVTYQGYSPY QLTWGRPSTRIQQQLGQLTLENLQMLPESEDEESYDTE SEFTEFTEDELPYDDCVFGGQRLTL
• Sequence Similarities: Belongs to the NF-kappa-B inhibitor family.Contains 5 ANK repeats.

Gene Information

• Gene Name: NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha [ Homo sapiens ]
• Official Symbol: NFKBIA
• Synonyms: NFKBIA; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha; NFKBI; NF-kappa-B inhibitor alpha; IkappaBalpha; IKBA; MAD 3
• Gene ID: 4792
• mRNA Refseq: NM_020529
• Protein Refseq: NP_065390
• MIM: 164008
• Uniprot ID: P25963
• Chromosome Location: 14q13
• Pathway: Activated TLR4 signalling, organism-specific biosystem; Adaptive Immune System, organism-specific biosystem; Adipocytokine signaling pathway, organism-specific biosystem; Adipocytokine signaling pathway, conserved biosystem; Apoptosis, organism-specific biosystem
• Function: NF-kappaB binding; NF-kappaB binding; enzyme binding; heat shock protein binding; identical protein binding