"NMNAT2" Related Products


Recombinant Human NMNAT2, His-tagged

Cat.No. : NMNAT2-28747TH
Product Overview : Recombinant full length Human NMNAT2 with an N terminal His tag; MWt 35 kDa .
Description : This gene product belongs to the nicotinamide mononucleotide adenylyltransferase (NMNAT) enzyme family, members of which catalyze an essential step in NAD (NADP) biosynthetic pathway. Unlike the other human family member, which is localized to the nucleus, and is ubiquitously expressed; this enzyme is cytoplasmic, and is predominantly expressed in the brain. Two transcript variants encoding different isoforms have been found for this gene.
Protein length : 306 amino acids
Conjugation : HIS
Molecular Weight : 35.000kDa inclusive of tags
Source : E. coli
Tissue specificity : Highly expressed in brain, in particular in cerebrum, cerebellum, occipital lobe, frontal lobe, temporal lobe and putamen. Also found in the heart, skeletal muscle, pancreas and islets of Langerhans.
Biological activity : Converts NMN to NAD+.
Form : Liquid
Purity : >90% by SDS-PAGE
Storage buffer : Preservative: NoneConstituents: 55mM Tris HCl, 150mM Sodium chloride, pH 8.2
Storage : Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Sequence Similarities : Belongs to the eukaryotic NMN adenylyltransferase family.
Gene Name : NMNAT2 nicotinamide nucleotide adenylyltransferase 2 [ Homo sapiens ]
Official Symbol : NMNAT2
Synonyms : NMNAT2; nicotinamide nucleotide adenylyltransferase 2; C1orf15, chromosome 1 open reading frame 15; nicotinamide mononucleotide adenylyltransferase 2; KIAA0479; PNAT2;
Gene ID : 23057
mRNA Refseq : NM_015039
Protein Refseq : NP_055854
MIM : 608701
Uniprot ID : Q9BZQ4
Chromosome Location : 1q25
Pathway : Metabolic pathways, organism-specific biosystem; Metabolism, organism-specific biosystem; Metabolism of vitamins and cofactors, organism-specific biosystem; Metabolism of water-soluble vitamins and cofactors, organism-specific biosystem; Nicotinate and nicotinamide metabolism, organism-specific biosystem;
Function : ATP binding; nicotinamide-nucleotide adenylyltransferase activity; nicotinate-nucleotide adenylyltransferase activity; nucleotide binding; nucleotidyltransferase activity;

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