"TNFRSF10D" Related Products


Recombinant Human TNFRSF10D

Cat. No. : TNFRSF10D-1693H
Description : TNF-related apoptosis-inducing ligand receptor 4 (TRAIL R4) is a decoy receptor that negatively regulate TRAIL-induced cytotoxicity by competing for ligand binding with TRAIL-R1 and TRAIL-R2.1 TRAIL R4 is expressed mainly on CD8+ and NK cells and induces apoptosis in many tumour cells, but not in normal cells. TRAIL-R4 contains partially truncated death domain and therefore is unable to induce apoptosis and serves as a negative regulator of apoptotic signaling by impairment death-inducing signaling complex (DISC) processing.
Molecular Weight : The predicted molecular weight of Recombinant Human TRAIL R4 is Mr 44.2 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 70-80 kDa.
Source : NSO Cells.
State Of Matter : Lyophilized.
Purity : >95% by SDS Page and analyzed by silver stain.
Endotoxin : <1.0 EU/µg as determined by the LAL method.
Storage And Stability : This lyophilized protein is stable for six to twelve months when stored desiccated at -20℃ to -70℃. After aseptic reconstitution, this protein may be stored at 2℃ to 8℃ for one month or at -20℃ to -70℃ in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Gene Name : TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain [ Homo sapiens ]
Synonyms : TNFRSF10D; tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain; DCR2; CD264; TRUNDD; TRAILR4; tumor necrosis factor receptor superfamily, member 10d; TRAIL receptor 4; decoy receptor 2; decoy with truncated death domain; TNF receptor-related receptor for TRAIL; TRAIL receptor with a truncated death domain; DcR2; TRAIL-R4; CD264 antigen; TNF-related apoptosis-inducing ligand receptor 4
Gene ID : 8793
mRNA Refseq : NM_003840
Protein Refseq : NP_003831
MIM : 603614
UniProt ID : Q9UBN6
Chromosome Location : 8p21
Pathway : Apoptosis; Cytokine-cytokine receptor interaction; Natural killer cell mediated cytotoxicity
Function : protein binding; transmembrane receptor activity

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