Recombinant Human PAG1, His-tagged

• Cat.No.: PAG1-30060TH
• Product Overview: Recombinant fragment, corresponding to intracellular amino acids 41/432 of Human PAG fused with a His tag at the N terminus.

Specification

• Description: The protein encoded by this gene is a type III transmembrane adaptor protein that binds to the tyrosine kinase csk protein. It is thought to be involved in the regulation of T cell activation.
• Conjugation: HIS
• Source: E. coli
• Tissue specificity: Ubiquitously expressed. Present in germinal center B-cells, plasma cells, T-cells, monocytes and platelets (at protein level).
• Form: Lyophilised:Reconstitute with 100 ul sterile deionized water. For long term storage or for preparation of more diluted working stock solution, a carrier protein (e.g. 1% serum albumin) should be added to the vial.
• Purity: >95% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 100mM Sodium chloride, 10mM Sodium phosphate, pH 8
• Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Gene Information

• Gene Name: PAG1 phosphoprotein associated with glycosphingolipid microdomains 1 [ Homo sapiens ]
• Official Symbol: PAG1
• Synonyms: PAG1; phosphoprotein associated with glycosphingolipid microdomains 1; phosphoprotein associated with glycosphingolipid-enriched microdomains 1; CBP; Csk binding protein; PAG; transmembrane adaptor protein PAG
• Gene ID: 55824
• mRNA Refseq: NM_018440
• Protein Refseq: NP_060910
• MIM: 605767
• Uniprot ID: Q9NWQ8
• Chromosome Location: 8q21.13
• Pathway: Adaptive Immune System, organism-specific biosystem; BCR signaling pathway, organism-specific biosystem; CXCR4-mediated signaling events, organism-specific biosystem; GAB1 signalosome, organism-specific biosystem; Immune System, organism-specific biosystem
• Function: SH2 domain binding; SH3/SH2 adaptor activity; protein binding