Recombinant Human PAK2 PAK2-30670TH

Recombinant Human PAK2

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Recombinant Human PAK2

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Cat.No. : PAK2-30670TH
Product Overview : Recombinant fragment, amino acids 227-524 of Human PAK2, expressed in E.coli, 33.35 kDa,
Description : The p21 activated kinases (PAK) are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. The PAK proteins are a family of serine/threonine kinases that serve as targets for the small GTP binding proteins, CDC42 and RAC1, and have been implicated in a wide range of biological activities. The protein encoded by this gene is activated by proteolytic cleavage during caspase-mediated apoptosis, and may play a role in regulating the apoptotic events in the dying cell.
Protein length : 298 amino acids
Molecular Weight : 33.350kDa
Source : E. coli
Biological activity : 86 nmoles/min/μgAnalysis of enzymatic activity: 1. Different concentrations of PAK2 were incubated in a buffer containing 50 mM HEPES (pH7.5), 10 mM MgCl2, 1 mM EGTA, 200 μM ATP, 0.01% Brij-35, and 2 μM substrate (SER/THR20) at room temperature for 1 hour
Form : Liquid
Purity : >90% by SDS-PAGE
Storage buffer : Preservative: NoneConstituents: 10% Glycerol, 5mM DTT, 25mM Tris HCl, 150mM Sodium chloride, pH 8.0
Storage : Shipped at 4°C. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Gene Name : PAK2 p21 protein (Cdc42/Rac)-activated kinase 2 [ Homo sapiens ]
Official Symbol : PAK2
Synonyms : PAK2; p21 protein (Cdc42/Rac)-activated kinase 2; p21 (CDKN1A) activated kinase 2; serine/threonine-protein kinase PAK 2; PAK65; PAKgamma; S6/H4 kinase;
Gene ID : 5062
mRNA Refseq : NM_002577
Protein Refseq : NP_002568
MIM : 605022
Uniprot ID : Q13177
Chromosome Location : 3q29
Pathway : Activation of Rac, organism-specific biosystem; Adaptive Immune System, organism-specific biosystem; Apoptosis, organism-specific biosystem; Apoptotic executionphase, organism-specific biosystem; Axon guidance, organism-specific biosystem;
Function : ATP binding; identical protein binding; nucleotide binding; protein binding; protein kinase activity;

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