Recombinant Human PAK4

• Cat.No.: PAK4-30671TH
• Product Overview: Recombinant full length Human PAK4 with N-terminal proprietary tag; MWt 90kDa.

Specification

• Description: PAK proteins, a family of serine/threonine p21-activating kinases, include PAK1, PAK2, PAK3 and PAK4. PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. They serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological activities. PAK4 interacts specifically with the GTP-bound form of Cdc42Hs and weakly activates the JNK family of MAP kinases. PAK4 is a mediator of filopodia formation and may play a role in the reorganization of the actin cytoskeleton. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
• Protein length: 591 amino acids
• Molecular Weight: 90.000kDa inclusive of tags
• Source: Baculovirus
• Tissue specificity: Highest expression in prostate, testis and colon.
• Biological activity: The specific activity of PAK4-30671TH was determined to be 72 nmol/min/mg.
• Form: Liquid
• Storage buffer: Preservative: NoneConstituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 10mM Glutathione, 0.25mM DTT, 0.1mM EDTA, 0.1mM PMSF, pH 7.5
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequence Similarities: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.Contains 1 CRIB domain.Contains 1 protein kinase domain.

Gene Information

• Gene Name: PAK4 p21 protein (Cdc42/Rac)-activated kinase 4 [ Homo sapiens ]
• Official Symbol: PAK4
• Synonyms: PAK4; p21 protein (Cdc42/Rac)-activated kinase 4; p21(CDKN1A) activated kinase 4; serine/threonine-protein kinase PAK 4
• Gene ID: 10298
• mRNA Refseq: NM_001014831
• Protein Refseq: NP_001014831
• MIM: 605451
• Uniprot ID: O96013
• Chromosome Location: 19p11-q11
• Pathway: Activation of Rac, organism-specific biosystem; Axon guidance, organism-specific biosystem; Axon guidance, conserved biosystem; Axon guidance, organism-specific biosystem; CDC42 signaling events, organism-specific biosystem
• Function: ATP binding; nucleotide binding; protein kinase activity; protein serine/threonine kinase activity

Reviews

11/16/2021

The prompt and knowledgeable assistance they offer has greatly enhanced my confidence in using the PAK4 protein.

03/01/2020

I am highly satisfied with the performance and support associated with this protein, as it has proven to be an essential tool in advancing my scientific investigations.

05/18/2016

Its purity and reliability have provided consistent and reliable results in my research.

Q&As

Are there any FDA-approved drugs targeting PAK4?

As of my knowledge cutoff date in January 2022, there were no FDA-approved drugs specifically targeting PAK4.

Are there any diagnostic tests based on PAK4 for cancer screening?

PAK4 is not commonly used as a specific diagnostic marker for cancer screening. Other markers, like PSA for prostate cancer or mammography for breast cancer, are more common.

What are the current clinical trials involving PAK4 inhibitors?

Clinical trials involving PAK4 inhibitors may vary over time. To find the latest information, you should consult clinical trial databases or healthcare professionals.

What are the challenges in developing PAK4 inhibitors for clinical use?

Selectivity and potential side effects are challenges in developing PAK4 inhibitors, which need to be carefully addressed in clinical trials.

How is PAK4-related research contributing to personalized medicine?

PAK4-related research may help identify specific patient populations that could benefit from PAK4-targeted therapies, contributing to personalized treatment approaches.