"PAK4" Related Products


Recombinant Human PAK4

Cat.No.: PAK4-30671TH
Product Overview: Recombinant full length Human PAK4 with N-terminal proprietary tag; MWt 90kDa.
Description: PAK proteins, a family of serine/threonine p21-activating kinases, include PAK1, PAK2, PAK3 and PAK4. PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. They serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological activities. PAK4 interacts specifically with the GTP-bound form of Cdc42Hs and weakly activates the JNK family of MAP kinases. PAK4 is a mediator of filopodia formation and may play a role in the reorganization of the actin cytoskeleton. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Protein length: 591 amino acids
Molecular Weight: 90.000kDa inclusive of tags
Source: Baculovirus
Tissue specificity: Highest expression in prostate, testis and colon.
Biological activity: The specific activity of PAK4-30671TH was determined to be 72 nmol/min/mg.
Form: Liquid
Storage buffer: Preservative: NoneConstituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 10mM Glutathione, 0.25mM DTT, 0.1mM EDTA, 0.1mM PMSF, pH 7.5
Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Sequence Similarities: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.Contains 1 CRIB domain.Contains 1 protein kinase domain.
Gene Name: PAK4 p21 protein (Cdc42/Rac)-activated kinase 4 [ Homo sapiens ]
Official Symbol: PAK4
Synonyms: PAK4; p21 protein (Cdc42/Rac)-activated kinase 4; p21(CDKN1A) activated kinase 4; serine/threonine-protein kinase PAK 4;
Gene ID: 10298
mRNA Refseq: NM_001014831
Protein Refseq: NP_001014831
MIM: 605451
Uniprot ID: O96013
Chromosome Location: 19p11-q11
Pathway: Activation of Rac, organism-specific biosystem; Axon guidance, organism-specific biosystem; Axon guidance, conserved biosystem; Axon guidance, organism-specific biosystem; CDC42 signaling events, organism-specific biosystem;
Function: ATP binding; nucleotide binding; protein kinase activity; protein serine/threonine kinase activity;

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