Expand Expand| Cat. No. : | TNFRSF14-1691H |
| Product Overview : | Recombinant Human TNFRSF14 was expressed in a mouse myeloma cell line,NSO.The DNA sequence encoding the extracellular domain of human HVEM was fused to the carboxy-terminal 6X histidine-tagged region of human IgG1 via a linker peptide and inserted into a suitable expression vector. |
| Description : | Tumor necrosis factor receptor superfamily member 14 (herpesvirus entry mediator), also known as TNFRSF14, is the cellular receptor for TNF superfamily 14 (LIGHT). TNFRSF14 is a type I membrane protein that is considered as a Herpesvirus entry mediator. It is able to inhibit the proliferation, activation, and cytokine production of T cells. TNFRSF14 is expressed by peripheral blood T cells, B cells, monocytes and in various tissues enriched in lymphoid cells. |
| Molecular Weight : | The predicted molecular weight of Recombinant Human TNFRSF14 is Mr 45 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 60 kDa. |
| Source : | NSO Cells. |
| Amino Acid Sequence : | N-Terminus: human HVEM (Met 1 - Val 202); IEGRMD Human IgG1 (Pro 100 - Lys 330); HHHHHH C-Terminus. |
| State Of Matter : | Lyophilized. |
| Formulation : | This recombinant protein was 0.2 µm filtered and lyophilized from modified Dulbecco's phosphate buffered saline (1X PBS) pH 7.2 – 7.3 with no calcium, magnesium, or preservatives present. |
| Purity : | >95% by SDS Page and analyzed by silver stain. |
| Endotoxin : | <0.1 ng per 1 µg as determined by the LAL method. |
| Biological Activity : | The biological activity of Human HVEM-Fc was determined by its ability to inhibit apoptosis of mouse L-929 cells treated with 0.1 ng/mL of rhTNF-β. The expected ED50 for this effect is typically 0.5 - 2 μg/mL. |
| Storage And Stability : | This lyophilized protein is stable for six to twelve months when stored desiccated at -20℃ to -70℃. After aseptic reconstitution, this protein may be stored at 2℃ to 8℃ for one month or at -20℃ to -70℃ in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions. |
| Gene Name : | TNFRSF14 tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator) [ Homo sapiens ] |
| Synonyms : | tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator); TR2; ATAR; HVEA; HVEM; LIGHTR; TNFRSF14; tumor necrosis factor receptor superfamily, member 14; CD40-like protein; herpesvirus entry mediator A; tumor necrosis factor receptor-like gene2; OTTHUMP00000000866; Herpesvirus entry mediator A; Tumor necrosis factor receptor-like 2 |
| Gene ID : | 8764 |
| mRNA Refseq : | NM_003820 |
| Protein Refseq : | NP_003811 |
| MIM : | 602746 |
| UniProt ID : | Q92956 |
| Chromosome Location : | 1p36.3-p36.2 |
| Pathway : | Cytokine-cytokine receptor interaction; Signaling in Immune system |
| Function : | tumor necrosis factor receptor activity; transmembrane receptor activity; protein binding |
Welcome! For price inquiries, please feel free to contact us through the form below. We will get back to you as soon as possible.
Download Datasheet
See All TNFRSF14 Products
Download Datasheet