Recombinant Human TNFRSF18, Fc Chimera


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Recombinant Human TNFRSF18, Fc Chimera

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Cat. No. : TNFRSF18-1621H
Product Overview : Recombinant Human TNFRSF18 encoding the signal peptide from hCD33 (Met 1 - Ala 16) joined with the extracellular domain of human GITR (amino acid residues 26 - 161) was fused to the Fc region of human IgG1 via a polypeptide linker and expressed inNSO cells.
Description : GITR (glucocorticoid-induced tumor necrosis factor receptor) also known as TNFRSF18, is a surface receptor molecule that has been shown to be involved in inhibiting the suppressive activity of T-regulatory cells and extending the survival of T-effector cells.1 GITR is involved in the regulation of T-cell receptor mediated cell death. Constitutive expression of a transfected GITR gene induces resistance to apoptosis induced by anti CD3 monoclonal antibodies. GITR ligand interferes with the suppressor activity of CD4(+) CD25(+) regulatory T-cells.
Source : Mammalian cells
State Of Matter : Lyophilized.
Purity : >90% by SDS Page and analyzed by silver stain.
Endotoxin : <1.0 EU/µg as determined by the LAL method.
Molecular Weight : The predicted molecular weight of Recombinant Human GITR is Mr 41 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 50 kDa.
Formulation : This recombinant protein was 0.2 µm filtered and lyophilized from modified Dulbecco's phosphate buffered saline (1X PBS) pH 7.2 – 7.3 with no calcium, magnesium, or preservatives.
Biological Activity : Measured by its ability to bind GITR ligand. Immobilized Human GITR at 2 μg/ml (100 μl/well) can bind Human GITR ligand with a linear range of 0.3 - 20 ng/ml in a functional ELISA assay.
Storage And Stability : This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Gene Name : TNFRSF18 tumor necrosis factor receptor superfamily, member 18 [ Homo sapiens ]
Synonyms : tumor necrosis factor receptor superfamily, member 18; AITR; GITR; GITR-D; TNFRSF18; activation-inducible TNFR family receptor; glucocorticoid-induced TNFR-related protein; TNF receptor superfamily activation-inducible protein; OTTHUMP00000001519; OTTHUMP00000001520; OTTHUMP00000001521; Activation-inducible TNFR family receptor; Glucocorticoid-induced TNFR-related protein
Gene ID : 8784
mRNA Refseq : NM_004195
Protein Refseq : NP_004186
MIM : 603905
UniProt ID : Q9Y5U5
Chromosome Location : 1p36.3
Pathway : Cytokine-cytokine receptor interaction
Function : receptor activity; tumor necrosis factor receptor activity
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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