"TNFRSF1B" Related Products

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Recombinant Human TNFRSF1B, Fc&His-tagged

Cat.No.: TNFRSF1B-1689H
Product Overview: Recombinant Human TNFRSF1B was expressed in NSO Cells.
Description: The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown, however, c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2, which mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways.
Source: NSO Cells
Species: Human
Tag: Fc&His
Form: Lyophilized. This recombinant protein was 0.2 µm filtered and lyophilized from modified Dulbecco’s phosphate buffered saline (1X PBS) pH 7.2 – 7.3 with no calcium, magnesium, or preservatives.
Molecular Mass: The predicted molecular weight of Recombinant Human TNF RII is Mr 52.6 kDa (monomer). However, the actual molecular weight as observed by migration on SDS Page is Mr 70 kDa.
AA Sequence: lpaqvaft pyapepgstc rlreyydqta qmccskcspg qhakvfctkt sdtvcdsced stytqlwnwv peclscgsrc ssdqvetqac treqnrictc rpgwycalsk qegcrlcapl rkcrpgfgva rpgtetsdvv ckpcapgtfs nttsstdicr phqicnvvai pgnasrdavc tstsptrsma pgavhlpqpv strsqhtqpt pepstapsts fllpmgpspp aegstgdieg rmdpkscdkt htcppcpape llggpsvflf ppkpkdtlmi srtpevtcvv vdvshedpev kfnwyvdgve vhnaktkpre eqynstyrvv svltvlhqdw lngkeykckv snkalpapie ktiskakgqp repqvytlpp srdeltknqv sltclvkgfy psdiavewes ngqpennykt tppvldsdgs fflyskltvd ksrwqqgnvf scsvmhealh nhytqkslsl spgkhhhhhh
Endotoxin: <1.0 EU/µg as determined by the LAL method
Purity: >95% by SDS-PAGE and analyzed by silver stain.
Storage: This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Gene Name: TNFRSF1B tumor necrosis factor receptor superfamily, member 1B [ Homo sapiens (human) ]
Official Symbol: TNFRSF1B
Synonyms: TNFRSF1B; p75; TBPII; TNFBR; TNFR2; CD120b; TNFR1B; TNFR80; TNF-R75; p75TNFR; TNF-R-II; tumor necrosis factor receptor superfamily, member 1B; tumor necrosis factor receptor superfamily member 1B; TNF-R2; TNF-RII; p75 TNF receptor; p80 TNF-alpha receptor; soluble TNFR1B variant 1; tumor necrosis factor receptor 2; tumor necrosis factor beta receptor; tumor necrosis factor receptor type II; tumor necrosis factor binding protein 2
Gene ID: 7133
mRNA Refseq: NM_001066
Protein Refseq: NP_001057
MIM: 191191
UniProt ID: P20333
Chromosome Location: 1p36.22
Pathway: Adipocytokine signaling pathway; Amyotrophic lateral sclerosis (ALS); Cytokine-cytokine receptor interaction
Function: protein binding; tumor necrosis factor-activated receptor activity; ubiquitin protein ligase binding

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