Recombinant Human PDE4B, GST-tagged

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Recombinant Human PDE4B, GST-tagged

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Cat.No. : PDE4B-30819TH
Product Overview : Recombinant full length PDE4B protein (Human) with an N terminal GST tag. MW 109kDa. Source: Baculovirus infected Sf9 cells.
Description : This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. Cyclic nucleotides are important second messengers that regulate and mediate a number of cellular responses to extracellular signals, such as hormones, light, and neurotransmitters. The cyclic nucleotide phosphodiesterases (PDEs) regulate the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. This gene encodes a protein that specifically hydrolyzes cAMP. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Conjugation : GST
Tissue specificity : Expressed in brain, heart, lung and skeletal muscle.
Biological activity : Specific Activity: 10000 U/μg.
Form : Liquid
Storage buffer : Preservative: NoneConstituents: 50% Glycerol, 0.05% Tween 20, 5mM Glutathione, 3mM DTT, 25mM Tris HCl, 100mM Sodium chloride, pH 8
Storage : Aliquot and store at -80°C. Avoid repeated freeze / thaw cycles.
Sequence Similarities : Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.
Gene Name : PDE4B phosphodiesterase 4B, cAMP-specific [ Homo sapiens ]
Official Symbol : PDE4B
Synonyms : PDE4B; phosphodiesterase 4B, cAMP-specific; DPDE4, phosphodiesterase 4B, cAMP specific (dunce (Drosophila) homolog phosphodiesterase E4) , phosphodiesterase 4B, cAMP specific (phosphodiesterase E4 dunce homolog, Drosophila); cAMP-specific 3,5-cyclic pho
Gene ID : 5142
mRNA Refseq : NM_001037339
Protein Refseq : NP_001032416
MIM : 600127
Uniprot ID : Q07343
Chromosome Location : 1p31
Pathway : DARPP-32 events, organism-specific biosystem; G Protein Signaling Pathways, organism-specific biosystem; G alpha (s) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; Myometrial Relaxation and Contraction Pathways, organism-specific biosystem;
Function : 3,5-cyclic-AMP phosphodiesterase activity; hydrolase activity; metal ion binding; phosphoric diester hydrolase activity;
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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