||Recombinant full length PDE4B protein (Human) with an N terminal GST tag. MW 109kDa. Source: Baculovirus infected Sf9 cells.
||This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. Cyclic nucleotides are important second messengers that regulate and mediate a number of cellular responses to extracellular signals, such as hormones, light, and neurotransmitters. The cyclic nucleotide phosphodiesterases (PDEs) regulate the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. This gene encodes a protein that specifically hydrolyzes cAMP. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
||Expressed in brain, heart, lung and skeletal muscle.
||Specific Activity: 10000 U/μg.
||Preservative: NoneConstituents: 50% Glycerol, 0.05% Tween 20, 5mM Glutathione, 3mM DTT, 25mM Tris HCl, 100mM Sodium chloride, pH 8
||Aliquot and store at -80°C. Avoid repeated freeze / thaw cycles.
||Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.