Recombinant Human PDE4B, GST-tagged
Cat.No. : | PDE4B-30819TH |
Product Overview : | Recombinant full length PDE4B protein (Human) with an N terminal GST tag. MW 109kDa. Source: Baculovirus infected Sf9 cells. |
- Specification
- Gene Information
- Related Products
Description : | This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. Cyclic nucleotides are important second messengers that regulate and mediate a number of cellular responses to extracellular signals, such as hormones, light, and neurotransmitters. The cyclic nucleotide phosphodiesterases (PDEs) regulate the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. This gene encodes a protein that specifically hydrolyzes cAMP. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. |
Conjugation : | GST |
Tissue specificity : | Expressed in brain, heart, lung and skeletal muscle. |
Biological activity : | Specific Activity: 10000 U/μg. |
Form : | Liquid |
Storage buffer : | Preservative: NoneConstituents: 50% Glycerol, 0.05% Tween 20, 5mM Glutathione, 3mM DTT, 25mM Tris HCl, 100mM Sodium chloride, pH 8 |
Storage : | Aliquot and store at -80°C. Avoid repeated freeze / thaw cycles. |
Sequence Similarities : | Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily. |
Gene Name : | PDE4B phosphodiesterase 4B, cAMP-specific [ Homo sapiens ] |
Official Symbol : | PDE4B |
Synonyms : | PDE4B; phosphodiesterase 4B, cAMP-specific; DPDE4, phosphodiesterase 4B, cAMP specific (dunce (Drosophila) homolog phosphodiesterase E4) , phosphodiesterase 4B, cAMP specific (phosphodiesterase E4 dunce homolog, Drosophila); cAMP-specific 3,5-cyclic pho |
Gene ID : | 5142 |
mRNA Refseq : | NM_001037339 |
Protein Refseq : | NP_001032416 |
MIM : | 600127 |
Uniprot ID : | Q07343 |
Chromosome Location : | 1p31 |
Pathway : | DARPP-32 events, organism-specific biosystem; G Protein Signaling Pathways, organism-specific biosystem; G alpha (s) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; Myometrial Relaxation and Contraction Pathways, organism-specific biosystem; |
Function : | 3,5-cyclic-AMP phosphodiesterase activity; hydrolase activity; metal ion binding; phosphoric diester hydrolase activity; |
Products Types
◆ Recombinant Protein | ||
PDE4B-0558H | Recombinant Human PDE4B Protein (S324-G691), Tag Free | +Inquiry |
PDE4B-3991R | Recombinant Rat PDE4B Protein, His (Fc)-Avi-tagged | +Inquiry |
PDE4B-0559H | Recombinant Human PDE4B Protein (S324-G691), His tagged | +Inquiry |
PDE4B-743H | Recombinant Human PDE4B Protein, MYC/DDK-tagged | +Inquiry |
PDE4B-147H | Recombinant Human PDE4B Protein, His/GST-tagged | +Inquiry |
◆ Lysates | ||
PDE4B-621HCL | Recombinant Human PDE4B cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
- Q&As
- Reviews
Q&As (0)
Ask a questionAsk a Question for All PDE4B Products
Required fields are marked with *
My Review for All PDE4B Products
Required fields are marked with *
0
Inquiry Basket