Recombinant Human PFDN6, His-tagged

• Cat.No.: PFDN6-26966TH
• Product Overview: Recombinant full length Human PFD6 with an N terminal His tag; 149aa, 16.7kDa inclusive of tag.

Specification

• Description: PFDN6 is a subunit of the heteromeric prefoldin complex that chaperones nascent actin (see MIM 102560) and alpha- and beta-tubulin (see MIM 602529 and MIM 191130, respectively) chains pending their transfer to the cytosolic chaperonin containing TCP1 (MIM 186980) (CCT) complex (Hansen et al.
• Protein length: 129 amino acids
• Conjugation: HIS
• Molecular Weight: 16.700kDa inclusive of tags
• Source: E. coli
• Form: Liquid
• Purity: >95% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 10% Glycerol, 0.1M Sodium chloride, 20mM Tris HCl, 1mM DTT, pH 8.0
• Storage: Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Sequences of amino acids: MGSSHHHHHHSSGLVPRGSHMAELI QKKLQGEVEKYQQLQKDLSKSMSGR QKLEAQLTENNIVKEELALLDGSNV VFKLLGPVLVKQELGEARATVGKRL DYITAEIKRYESQLRDLERQSEQQR ETLAQLQQEFQRAQAAKAGAPGKA
• Sequence Similarities: Belongs to the prefoldin subunit beta family.

Gene Information

• Gene Name: PFDN6 prefoldin subunit 6 [ Homo sapiens ]
• Official Symbol: PFDN6
• Synonyms: PFDN6; prefoldin subunit 6; HKE2, HLA class II region expressed gene KE2 , prefoldin 6; H2 KE2; KE 2; PFD6
• Gene ID: 10471
• mRNA Refseq: NM_001185181
• Protein Refseq: NP_001172110
• MIM: 605660
• Uniprot ID: O15212
• Chromosome Location: 6p21.3
• Pathway: Chaperonin-mediated protein folding, organism-specific biosystem; Cooperation of Prefoldin and TriC/CCTin actin and tubulin folding, organism-specific biosystem; Metabolism of proteins, organism-specific biosystem; Prefoldin mediated transfer of substrateto CCT/TriC, organism-specific biosystem; Protein folding, organism-specific biosystem
• Function: chaperone binding; unfolded protein binding