||Recombinant full length Human PI 3 Kinase catalytic subunit gamma expressed in Sf9 insect cells with N terminal proprietary tag; amino acids 1-1102, 126.3 kDa.
||This gene encodes a protein that belongs to the pi3/pi4-kinase family of proteins. The gene product is an enzyme that phosphorylates phosphoinositides on the 3-hydroxyl group of the inositol ring. It is an important modulator of extracellular signals, including those elicited by E-cadherin-mediated cell-cell adhesion, which plays an important role in maintenance of the structural and functional integrity of epithelia. In addition to its role in promoting assembly of adherens junctions, the protein is thought to play a pivotal role in the regulation of cytotoxicity in NK cells. The gene is located in a commonly deleted segment of chromosome 7 previously identified in myeloid leukemias.
||Pancreas, skeletal muscle, liver and heart.
||>95% by SDS-PAGE
||Preservative: NoneConstituents: 50% Glycerol, 50mM Sodium chloride, 25mM Tris HCl, 0.5mM Magnesium chloride, pH 8.0
||Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
||Belongs to the PI3/PI4-kinase family.Contains 1 PI3K/PI4K domain.