Recombinant Human PIK3CG

• Cat.No.: PIK3CG-29586TH
• Product Overview: Recombinant full length Human PI 3 Kinase catalytic subunit gamma expressed in Sf9 insect cells with N terminal proprietary tag; amino acids 1-1102, 126.3 kDa.

Specification

• Description: This gene encodes a protein that belongs to the pi3/pi4-kinase family of proteins. The gene product is an enzyme that phosphorylates phosphoinositides on the 3-hydroxyl group of the inositol ring. It is an important modulator of extracellular signals, including those elicited by E-cadherin-mediated cell-cell adhesion, which plays an important role in maintenance of the structural and functional integrity of epithelia. In addition to its role in promoting assembly of adherens junctions, the protein is thought to play a pivotal role in the regulation of cytotoxicity in NK cells. The gene is located in a commonly deleted segment of chromosome 7 previously identified in myeloid leukemias.
• Tissue specificity: Pancreas, skeletal muscle, liver and heart.
• Form: Liquid
• Purity: >95% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 50% Glycerol, 50mM Sodium chloride, 25mM Tris HCl, 0.5mM Magnesium chloride, pH 8.0
• Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
• Sequence Similarities: Belongs to the PI3/PI4-kinase family.Contains 1 PI3K/PI4K domain.

Gene Information

• Gene Name: PIK3CG phosphoinositide-3-kinase, catalytic, gamma polypeptide [ Homo sapiens ]
• Official Symbol: PIK3CG
• Synonyms: PIK3CG; phosphoinositide-3-kinase, catalytic, gamma polypeptide; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
• Gene ID: 5294
• mRNA Refseq: NM_002649
• Protein Refseq: NP_002640
• MIM: 601232
• Uniprot ID: P48736
• Chromosome Location: 7q22
• Pathway: 3-phosphoinositide biosynthesis, conserved biosystem; Acute myeloid leukemia, organism-specific biosystem; Acute myeloid leukemia, conserved biosystem; Aldosterone-regulated sodium reabsorption, organism-specific biosystem; Aldosterone-regulated sodium reabsorption, conserved biosystem
• Function: 1-phosphatidylinositol-3-kinase activity; ATP binding; ephrin receptor binding; kinase activity; nucleotide binding