Recombinant Human Human PIK3CG, His-tagged

• Cat.No.: PIK3R5-31760TH
• Product Overview: Human recombinant Full Length proteins: PI 3 Kinase catalytic subunit gamma and PIK3R5.The PI 3 Kinase catalytic subunit gamma carries a N-terminal X6His Tag, whereas the PIK3R5 adaptor subunit carries a N-terminal enzyme tag.The molecular weight for PI 3

Specification

• Description: Phosphatidylinositol 3-kinases (PI3Ks) phosphorylate the inositol ring of phosphatidylinositol at the 3-prime position, and play important roles in cell growth, proliferation, differentiation, motility, survival and intracellular trafficking. The PI3Ks are divided into three classes: I, II and III, and only the class I PI3Ks are involved in oncogenesis. This gene encodes the 101 kD regulatory subunit of the class I PI3K gamma complex, which is a dimeric enzyme, consisting of a 110 kD catalytic subunit gamma and a regulatory subunit of either 55, 87 or 101 kD. This protein recruits the catalytic subunit from the cytosol to the plasma membrane through high-affinity interaction with G-beta-gamma proteins. Multiple alternatively spliced transcript variants encoding two distinct isoforms have been found.
• Conjugation: HIS
• Biological activity: Activity: ~ 3 nmol/mg/min using phosphatidylinositol as the substrate.
• Form: Liquid
• Purity: >95% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 50% Glycerol, 25mM Sodium chloride, 25mM HEPES, 2.5mM Magnesium chloride, pH 8.0
• Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Gene Information

• Gene Name: PIK3R5 phosphoinositide-3-kinase, regulatory subunit 5 [ Homo sapiens ]
• Official Symbol: PIK3R5
• Synonyms: PIK3R5; phosphoinositide-3-kinase, regulatory subunit 5; phosphoinositide 3-kinase regulatory subunit 5; p101; P101 PI3K
• Gene ID: 23533
• mRNA Refseq: NM_001251852
• Protein Refseq: NP_001238781
• MIM: 611317
• Uniprot ID: Q8WYR1
• Chromosome Location: 17p13.1
• Pathway: 3-phosphoinositide biosynthesis, conserved biosystem; Acute myeloid leukemia, organism-specific biosystem; Acute myeloid leukemia, conserved biosystem; Aldosterone-regulated sodium reabsorption, organism-specific biosystem; Aldosterone-regulated sodium reabsorption, conserved biosystem
• Function: 1-phosphatidylinositol-3-kinase regulator activity; phosphatidylinositol-4,5-bisphosphate 3-kinase activity