||Human recombinant Full Length proteins: PI 3 Kinase catalytic subunit gamma and PIK3R5.The PI 3 Kinase catalytic subunit gamma carries a N-terminal X6His Tag, whereas the PIK3R5 adaptor subunit carries a N-terminal enzyme tag.The molecular weight for PI 3
||Phosphatidylinositol 3-kinases (PI3Ks) phosphorylate the inositol ring of phosphatidylinositol at the 3-prime position, and play important roles in cell growth, proliferation, differentiation, motility, survival and intracellular trafficking. The PI3Ks are divided into three classes: I, II and III, and only the class I PI3Ks are involved in oncogenesis. This gene encodes the 101 kD regulatory subunit of the class I PI3K gamma complex, which is a dimeric enzyme, consisting of a 110 kD catalytic subunit gamma and a regulatory subunit of either 55, 87 or 101 kD. This protein recruits the catalytic subunit from the cytosol to the plasma membrane through high-affinity interaction with G-beta-gamma proteins. Multiple alternatively spliced transcript variants encoding two distinct isoforms have been found.
||Activity: ~ 3 nmol/mg/min using phosphatidylinositol as the substrate.
||>95% by SDS-PAGE
||Preservative: NoneConstituents: 50% Glycerol, 25mM Sodium chloride, 25mM HEPES, 2.5mM Magnesium chloride, pH 8.0
||Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.