"PINK1" Related Products

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Recombinant Human PINK1

Cat.No.: PINK1-30963TH
Product Overview: Recombinant fragment of Human PINK1 , 353 amino acids with a predicted Mwt of 37.9 kDa
Description: This gene encodes a serine/threonine protein kinase that localizes to mitochondria. It is thought to protect cells from stress-induced mitochondrial dysfunction. Mutations in this gene cause one form of autosomal recessive early-onset Parkinson disease.
Protein length: 352 amino acids
Molecular Weight: 37.900kDa
Source: E. coli
Tissue specificity: Highly expressed in heart, skeletal muscle and testis, and at lower levels in brain, placenta, liver, kidney, pancreas, prostate, ovary and small intestine. Present in the embryonic testis from an early stage of development.
Form: Liquid
Purity: >90% by SDS-PAGE
Storage buffer: pH: 8.00Constituents:5% Glycerol, 6.01% Urea, 0.32% Tris HCl
Storage: Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Sequences of amino acids: MYLIGQSIGK GCSAAVYEAT MPTLPQNLEV TKSTGLLPGR GPGTSAPGEG QERAPGAPAF PLAIKMMWNI SAGSSSEAIL NTMSQELVPA SRVALAGEYG AVTYRKSKRG PKQLAPHPNI IRVLRAFTSS VPLLPGALVD YPDVLPSRLH PEGLGHGRTL FLVMKNYPCT LRQYLCVNTP SPRLAAMMLL QLLEGVDHLV QQGIAHRDLK SDNILVELDP DGCPWLVIAD FGCCLADESI GLQLPFSSWY VDRGGNGCLM APEVSTARPG PRAVIDYSKA DAWAVGAIAY EIFGLVNPFY GQGKAHLESR SYQEAQLPAL PESVPPDVRQ LVRALLQREA SKRPSARVAA NVL
Sequence Similarities: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.Contains 1 protein kinase domain.
Gene Name: PINK1 PTEN induced putative kinase 1 [ Homo sapiens ]
Official Symbol: PINK1
Synonyms: PINK1; PTEN induced putative kinase 1; PARK6, Parkinson disease (autosomal recessive) 6; serine/threonine-protein kinase PINK1, mitochondrial;
Gene ID: 65018
mRNA Refseq: NM_032409
Protein Refseq: NP_115785
MIM: 608309
Uniprot ID: Q9BXM7
Chromosome Location: 1p36.12
Pathway: Parkinsons disease, organism-specific biosystem;
Function: ATP binding; C3HC4-type RING finger domain binding; calcium-dependent protein kinase activity; kinase activity; magnesium ion binding;

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